Next Article in Journal
Hexaborate(2−) and Dodecaborate(6−) Anions as Ligands to Zinc(II) Centres: Self-Assembly and Single-Crystal XRD Characterization of [Zn{κ3O-B6O7(OH)6}(κ3N-dien)]·0.5H2O (dien = NH(CH2–CH2NH2)2), (NH4)2[Zn{κ2O-B6O7(OH)6}2 (H2O)2]·2H2O and (1,3-pnH2)3[(κ1N-H3N{CH2}3NH2) Zn{κ3O-B12O18(OH)6}]2·14H2O (1,3-pn = 1,3-diaminopropane)
Next Article in Special Issue
Potential of MRI in Radiotherapy Mediated by Small Conjugates and Nanosystems
Previous Article in Journal
Understanding Factors that Control the Structural (Dis)Assembly of Sulphur-Bridged Bimetallic Sites
Previous Article in Special Issue
Ferritin: A Platform for MRI Contrast Agents Delivery
Article Menu
Issue 4 (April) cover image

Export Article

Open AccessArticle

Electronic Effects of the Substituents on Relaxometric and CEST Behaviour of Ln(III)-DOTA-Tetraanilides

Dipartimento of Scienze e Innovazione Tecnologica, Università del Piemonte Orientale, Viale T. Michel 11, 15121 Alessandria, Italy
Department of Chemistry, University of Torino, via Giuria 7, I-10125 Torino, Italy
Author to whom correspondence should be addressed.
Inorganics 2019, 7(4), 43;
Received: 31 January 2019 / Revised: 8 March 2019 / Accepted: 11 March 2019 / Published: 27 March 2019
(This article belongs to the Special Issue MRI Contrast Agents)
PDF [3388 KB, uploaded 27 March 2019]


Three different 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetamide (DOTAM) derivatives bearing as amide N-substituents phenyl, p-methoxyphenyl and p-ethylbenzoate groups were synthesized and the 1H and 17O NMR relaxometric behaviour of the Gd(III)-chelates and chemical exchange saturation transfer (CEST) effect of the Eu(III) complexes were evaluated. The electronic properties of the substituents were shown to strongly influence the coordinated water exchange rate (kex), resulting in five times faster kex for the electron donating phenylmethoxy group compared to the electron withdrawing ethylbenzoate group. View Full-Text
Keywords: macrocyclic ligands; lanthanide complexes; relaxometry; CEST; electronic effects macrocyclic ligands; lanthanide complexes; relaxometry; CEST; electronic effects

Graphical abstract

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Supplementary material


Share & Cite This Article

MDPI and ACS Style

Lagostina, V.; Leone, L.; Carniato, F.; Digilio, G.; Tei, L.; Botta, M. Electronic Effects of the Substituents on Relaxometric and CEST Behaviour of Ln(III)-DOTA-Tetraanilides. Inorganics 2019, 7, 43.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Inorganics EISSN 2304-6740 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top