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Electronic Effects of the Substituents on Relaxometric and CEST Behaviour of Ln(III)-DOTA-Tetraanilides

1
Dipartimento of Scienze e Innovazione Tecnologica, Università del Piemonte Orientale, Viale T. Michel 11, 15121 Alessandria, Italy
2
Department of Chemistry, University of Torino, via Giuria 7, I-10125 Torino, Italy
*
Author to whom correspondence should be addressed.
Inorganics 2019, 7(4), 43; https://doi.org/10.3390/inorganics7040043
Received: 31 January 2019 / Revised: 8 March 2019 / Accepted: 11 March 2019 / Published: 27 March 2019
(This article belongs to the Special Issue MRI Contrast Agents)
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Abstract

Three different 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetamide (DOTAM) derivatives bearing as amide N-substituents phenyl, p-methoxyphenyl and p-ethylbenzoate groups were synthesized and the 1H and 17O NMR relaxometric behaviour of the Gd(III)-chelates and chemical exchange saturation transfer (CEST) effect of the Eu(III) complexes were evaluated. The electronic properties of the substituents were shown to strongly influence the coordinated water exchange rate (kex), resulting in five times faster kex for the electron donating phenylmethoxy group compared to the electron withdrawing ethylbenzoate group. View Full-Text
Keywords: macrocyclic ligands; lanthanide complexes; relaxometry; CEST; electronic effects macrocyclic ligands; lanthanide complexes; relaxometry; CEST; electronic effects
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Lagostina, V.; Leone, L.; Carniato, F.; Digilio, G.; Tei, L.; Botta, M. Electronic Effects of the Substituents on Relaxometric and CEST Behaviour of Ln(III)-DOTA-Tetraanilides. Inorganics 2019, 7, 43.

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