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Ferritin: A Platform for MRI Contrast Agents Delivery

Department of Molecular Biotechnology and Health Sciences, University of Torino, via Nizza 52, 10126 Torino, Italy
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Inorganics 2019, 7(3), 33; https://doi.org/10.3390/inorganics7030033
Received: 13 January 2019 / Revised: 24 February 2019 / Accepted: 25 February 2019 / Published: 2 March 2019
(This article belongs to the Special Issue MRI Contrast Agents)
The search for high relaxivities and increased specificity continues to be central to the development of paramagnetic contrast agents for magnetic resonance imaging (MRI). Ferritin, due to its unique surface properties, architecture, and biocompatibility, has emerged as a natural nanocage that can potentially help to reach both these goals. This review aims to highlight recent advances in the use of ferritin as a nanoplatform for the delivery of metal-based MRI contrast agents (containing Gd3+, Mn2+, or Fe2O3) alone or in combination with active molecules used for therapeutic purposes. The collected results unequivocally show that the use of ferritin for contrast agent delivery leads to more accurate imaging of cancer cells and a significantly improved targeted therapy. View Full-Text
Keywords: ferritin; relaxation; molecular imaging; gene expression reporters; theranostic agents ferritin; relaxation; molecular imaging; gene expression reporters; theranostic agents
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MDPI and ACS Style

Ruggiero, M.R.; Alberti, D.; Bitonto, V.; Geninatti Crich, S. Ferritin: A Platform for MRI Contrast Agents Delivery. Inorganics 2019, 7, 33.

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