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Open AccessArticle

1H NMR Relaxometric Analysis of Paramagnetic Gd2O3:Yb Nanoparticles Functionalized with Citrate Groups

Department of Sciences and Technological Innovation, University of Eastern Piedmont, V. le T. Michel 11, 15121 Alessandria, Italy
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Inorganics 2019, 7(3), 34; https://doi.org/10.3390/inorganics7030034
Received: 31 January 2019 / Revised: 26 February 2019 / Accepted: 27 February 2019 / Published: 4 March 2019
Gd2O3 nanoparticles doped with different amount of Yb3+ ions and coated with citrate molecules were prepared by a cheap and fast co-precipitation procedure and proposed as potential “positive” contrast agents in magnetic resonance imaging. The citrate was used to improve the aqueous suspension, limiting particles precipitation. The relaxometric properties of the samples were studied in aqueous solution as a function of the magnetic field strength in order to evaluate the interaction of the paramagnetic ions exposed on the surface with the water molecules in proximity. The nanoparticles showed high relaxivity values at a high magnetic field with respect to the clinically used Gd3+-chelates and comparable to those of similar nanosytems. Special attention was also addressed to the investigation of the chemical stability of the nanoparticles in biological fluid (reconstructed human serum) and in the presence of a chelating agent. View Full-Text
Keywords: paramagnetic properties; gadolinium oxide; relaxation agents; nanoparticles paramagnetic properties; gadolinium oxide; relaxation agents; nanoparticles
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Carniato, F.; Gatti, G. 1H NMR Relaxometric Analysis of Paramagnetic Gd2O3:Yb Nanoparticles Functionalized with Citrate Groups. Inorganics 2019, 7, 34.

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