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Inorganics
Volume 13
Issue 8
10.3390/inorganics13080263
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Article

Manganese(II) Complexes with 3,5–Dibromosalicylaldehyde: Characterization and Interaction Studies with DNA and Albumins

by
Vasia Theodoulou
,
Ariadni Zianna
,
Antonios G. Hatzidimitriou
and
George Psomas
*
Laboratory of Inorganic Chemistry, Department of Chemistry, Aristotle University of Thessaloniki, GR–54124 Thessaloniki, Greece
*
Author to whom correspondence should be addressed.
Inorganics 2025, 13(8), 263; https://doi.org/10.3390/inorganics13080263
Submission received: 9 July 2025 / Revised: 30 July 2025 / Accepted: 11 August 2025 / Published: 12 August 2025
(This article belongs to the Special Issue Biological Activity of Metal Complexes)
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Abstract

The interaction of manganese(II) with deprotonated 3,5–dibromo–salicylaldehyde (3,5–diBr–saloH) in the absence or the presence of the N,N′-donors 2,2′–bipyridylamine (bipyam), 2,2′–bipyridine (bipy), 1,10–phenanthroline (phen), and 2,9–dimethyl–1,10–phenanthroline (neoc) as co-ligands yielded five neutral mononuclear complexes, namely Mn(3,5-diBr-salo)2(CH3OH)2] (complex 1), [Mn(3,5-diBr-salo)2(bipyam)] (complex 2), [Mn(3,5-diBr-salo)2(bipy)] (complex 3), [Mn(3,5-diBr-salo)2(phen)] (complex 4), and [Mn(3,5-diBr-salo)2(neoc)] (complex 5), respectively. The resultant complexes were characterized with physicochemical and spectroscopic techniques, and single-crystal X-ray crystallography was applied to determine the crystal structure of complex 2. The evaluation of the potential biological profile of the complexes focused on the interaction with linear calf-thymus (CT) DNA, and bovine (BSA) and human (HSA) serum albumin. According to the data derived, the complexes interact intercalatively and strongly with CT DNA and associate tightly and reversibly with both albumins studied.
Keywords: manganese(II) complexes; 3,5–dibromosalicylaldehyde; interaction with DNA; interaction with albumins manganese(II) complexes; 3,5–dibromosalicylaldehyde; interaction with DNA; interaction with albumins

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MDPI and ACS Style

Theodoulou, V.; Zianna, A.; Hatzidimitriou, A.G.; Psomas, G. Manganese(II) Complexes with 3,5–Dibromosalicylaldehyde: Characterization and Interaction Studies with DNA and Albumins. Inorganics 2025, 13, 263. https://doi.org/10.3390/inorganics13080263

AMA Style

Theodoulou V, Zianna A, Hatzidimitriou AG, Psomas G. Manganese(II) Complexes with 3,5–Dibromosalicylaldehyde: Characterization and Interaction Studies with DNA and Albumins. Inorganics. 2025; 13(8):263. https://doi.org/10.3390/inorganics13080263

Chicago/Turabian Style

Theodoulou, Vasia, Ariadni Zianna, Antonios G. Hatzidimitriou, and George Psomas. 2025. "Manganese(II) Complexes with 3,5–Dibromosalicylaldehyde: Characterization and Interaction Studies with DNA and Albumins" Inorganics 13, no. 8: 263. https://doi.org/10.3390/inorganics13080263

APA Style

Theodoulou, V., Zianna, A., Hatzidimitriou, A. G., & Psomas, G. (2025). Manganese(II) Complexes with 3,5–Dibromosalicylaldehyde: Characterization and Interaction Studies with DNA and Albumins. Inorganics, 13(8), 263. https://doi.org/10.3390/inorganics13080263

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