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Applications of Gas Chromatography for the Analysis of Tricyclic Antidepressants in Biological Matrices

Laboratory of Analytical Chemistry, Department of Chemistry, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece
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Separations 2019, 6(2), 24; https://doi.org/10.3390/separations6020024
Received: 30 January 2019 / Revised: 24 April 2019 / Accepted: 24 April 2019 / Published: 29 April 2019
(This article belongs to the Special Issue Five Years of Separations: Feature Paper 2018)
Tricyclic antidepressant drugs (TCAs) are a main category of antidepressants, which are until today widely used for the treatment of psychological disorders due to their low cost and their high efficiency. Therefore, there is a great demand for method development for the determination of TCAs in biofluids, especially for therapeutic drug monitoring. Gas chromatography (GC) was the first chromatographic technique implemented for this purpose. With the recent development in the field of sample preparation, many novel GC applications have been developed. Herein, we aim to report the recent application of GC for the determination of tricyclic antidepressants in biofluids. Emphasis is given to novel extraction techniques and novel materials used for sample preparation. View Full-Text
Keywords: gas chromatography; tricyclic antidepressants (TCAs); sample treatment; biological fluids gas chromatography; tricyclic antidepressants (TCAs); sample treatment; biological fluids
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Manousi, N.; Samanidou, V.F. Applications of Gas Chromatography for the Analysis of Tricyclic Antidepressants in Biological Matrices. Separations 2019, 6, 24.

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