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Dissolution Testing of Single- and Dual-Component Thyroid Hormone Supplements

Department of Applied Sciences, Northumbria University, Ellison Building, Newcastle upon Tyne NE1 8ST, UK
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Separations 2019, 6(1), 18; https://doi.org/10.3390/separations6010018
Received: 27 November 2018 / Revised: 19 February 2019 / Accepted: 6 March 2019 / Published: 26 March 2019
(This article belongs to the Special Issue Five Years of Separations: Feature Paper 2018)
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Abstract

A method for the analysis of thyroid hormones by liquid chromatography-mass spectrometry was used for the dissolution testing of single- and dual-component thyroid hormone supplements via a two-stage biorelevant dissolution procedure. The biorelevant media consisted of fasted-state simulated gastric fluid and fasted state simulated intestinal fluid at 37 °C, and was investigated using an internationally recognized protocol. The dissolution profiles showed consistent solubilization for both single- and dual-component batches at pH 6.5 in the fasted-state simulated intestinal fluid. View Full-Text
Keywords: thyroid; dissolution; liquid chromatography-mass spectrometry thyroid; dissolution; liquid chromatography-mass spectrometry
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Bowerbank, S.L.; Carlin, M.G.; Dean, J.R. Dissolution Testing of Single- and Dual-Component Thyroid Hormone Supplements. Separations 2019, 6, 18.

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