Next Article in Journal
Evaluating the Adsorbed Water Layer on Polar Stationary Phases for Hydrophilic Interaction Chromatography (HILIC)
Next Article in Special Issue
Treatment of Tannery Wastewater with Vibratory Shear-Enhanced Processing Membrane Filtration
Previous Article in Journal
Perfluoroalkyl Substance Assessment in Turin Metropolitan Area and Correlation with Potential Sources of Pollution According to the Water Safety Plan Risk Management Approach
Previous Article in Special Issue
Estimating Diphenylamine in Gunshot Residues from a New Tool for Identifying both Inorganic and Organic Residues in the Same Sample
Article Menu
Issue 1 (March) cover image

Export Article

Open AccessArticle

Dissolution Testing of Single- and Dual-Component Thyroid Hormone Supplements

Department of Applied Sciences, Northumbria University, Ellison Building, Newcastle upon Tyne NE1 8ST, UK
Author to whom correspondence should be addressed.
Separations 2019, 6(1), 18;
Received: 27 November 2018 / Revised: 19 February 2019 / Accepted: 6 March 2019 / Published: 26 March 2019
(This article belongs to the Special Issue Five Years of Separations: Feature Paper 2018)
PDF [874 KB, uploaded 26 March 2019]


A method for the analysis of thyroid hormones by liquid chromatography-mass spectrometry was used for the dissolution testing of single- and dual-component thyroid hormone supplements via a two-stage biorelevant dissolution procedure. The biorelevant media consisted of fasted-state simulated gastric fluid and fasted state simulated intestinal fluid at 37 °C, and was investigated using an internationally recognized protocol. The dissolution profiles showed consistent solubilization for both single- and dual-component batches at pH 6.5 in the fasted-state simulated intestinal fluid. View Full-Text
Keywords: thyroid; dissolution; liquid chromatography-mass spectrometry thyroid; dissolution; liquid chromatography-mass spectrometry

Graphical abstract

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Share & Cite This Article

MDPI and ACS Style

Bowerbank, S.L.; Carlin, M.G.; Dean, J.R. Dissolution Testing of Single- and Dual-Component Thyroid Hormone Supplements. Separations 2019, 6, 18.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Metrics

Article Access Statistics



[Return to top]
Separations EISSN 2297-8739 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top