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Open AccessArticle

Dissolution Testing of Single- and Dual-Component Thyroid Hormone Supplements

Department of Applied Sciences, Northumbria University, Ellison Building, Newcastle upon Tyne NE1 8ST, UK
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Separations 2019, 6(1), 18; https://doi.org/10.3390/separations6010018
Received: 27 November 2018 / Revised: 19 February 2019 / Accepted: 6 March 2019 / Published: 26 March 2019
(This article belongs to the Special Issue Five Years of Separations: Feature Paper 2018)
A method for the analysis of thyroid hormones by liquid chromatography-mass spectrometry was used for the dissolution testing of single- and dual-component thyroid hormone supplements via a two-stage biorelevant dissolution procedure. The biorelevant media consisted of fasted-state simulated gastric fluid and fasted state simulated intestinal fluid at 37 °C, and was investigated using an internationally recognized protocol. The dissolution profiles showed consistent solubilization for both single- and dual-component batches at pH 6.5 in the fasted-state simulated intestinal fluid. View Full-Text
Keywords: thyroid; dissolution; liquid chromatography-mass spectrometry thyroid; dissolution; liquid chromatography-mass spectrometry
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MDPI and ACS Style

Bowerbank, S.L.; Carlin, M.G.; Dean, J.R. Dissolution Testing of Single- and Dual-Component Thyroid Hormone Supplements. Separations 2019, 6, 18.

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