Extraction and Isolation of Kaempferol Glycosides from the Leaves and Twigs of Lindera neesiana
by
Anjana Adhikari-Devkota 1, Amina Ibrahim Dirar 1, Ayumi Kurizaki 2, Kazuki Tsushiro 2 and 
Hari Prasad Devkota 1,3,*
Anjana Adhikari-Devkota 1, Amina Ibrahim Dirar 1, Ayumi Kurizaki 2, Kazuki Tsushiro 2 and Hari Prasad Devkota 1,3,*
1
Graduate School of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-honmachi, Chuo-ku, Kumamoto 862-0973, Japan
2
School of Pharmacy, Kumamoto University, 5-1 Oe-honmachi, Chuo-ku, Kumamoto 862-0973, Japan
3
Program for Leading Graduate Schools, Health Life Science: Interdisciplinary and Glocal Oriented (HIGO) Program, Kumamoto University, 5-1 Oe-honmachi, Chuo-ku, Kumamoto 862-0973, Japan
*
Author to whom correspondence should be addressed.
Separations 2019, 6(1), 10; https://doi.org/10.3390/separations6010010
Received: 11 January 2019 / Revised: 29 January 2019 / Accepted: 5 February 2019 / Published: 13 February 2019
(This article belongs to the Special Issue Extraction and Isolation of Natural Products)
The hydroalcoholic extract of leaves and twigs of Lindera neesiana (Wall. ex Nees) Kurz (Lauraceae) was subjected to various column chromatographic methods that isolated five kaempferol glycosides: kaempferol 3-O-β-glucopyranosyl(1→2)-[α-rhamnopyranosyl-(1→6)]-β- glucopyranoside-7-O-α-rhamnopyranoside (1); kaempferol 3-O-β-glucopyranosyl-(1→2)-[α-rhamnopyranosyl (1→6)]-β-glucopyranoside (2); kaempferol 3-O-β-glucopyranosyl(1→2)- α-rhamnopyranoside-7-O-α-rhamnopyranoside (3); kaempferol 3-O-sophoroside (4); and kaempferol 3-O-α-rhamnopyranoside (5). The extract showed moderate free radical scavenging activity and potent pancreatic lipase inhibitory activity.
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Keywords:
Lindera neesiana; Siltimur; kaempferol glycosides; free radical scavenging; lipase inhibitory
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MDPI and ACS Style
Adhikari-Devkota, A.; Dirar, A.I.; Kurizaki, A.; Tsushiro, K.; Devkota, H.P. Extraction and Isolation of Kaempferol Glycosides from the Leaves and Twigs of Lindera neesiana. Separations 2019, 6, 10.
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