Nontuberculous mycobacteria (NTM) are ubiquitous environmental organisms capable of causing diverse clinical manifestations. Their epidemiology among people with HIV remains insufficiently characterized. This study examined the epidemiology of NTM among people with HIV admitted to the Hospital for Infectious Diseases in Warsaw between 2017 and 2023. Data on CD4+ T-cell counts, type of NTM involvement, species identification, and antimicrobial resistance were obtained from medical records. In the analyzed group the median of the CD4+ T-cell count was 25 cells/mm
3 (IQR 65 cells/mm
3). Late HIV diagnosis was observed in
n = 45/50 (90.0%) patients. NTM colonization was identified in
n = 20 (33.9%) patients, while
n = 39 (66.1%) had active NTM disease, including pulmonary (53.9%), disseminated (41.0%), and extrapulmonary (5.1%) forms.
Mycobacterium kansasii was the most common species among colonized patients,
n = 7/24 (29.2%), whereas
Mycobacterium avium predominated among patients with NTM disease,
n = 30/42 (71.4%). Among patients with NTM disease, in vitro resistance to at least one antimicrobial agent was observed in 80.0% of
M. avium isolates. High levels of resistance of
M. avium were noted for ethambutol (
n = 8/8, 100%), moxifloxacin (
n = 16/22, 72.8%) and linezolid (
n = 9/21, 42.9%). Proper identification of
Mycobacterium species and its antibiotic resistance might be helpful in selecting effective antimicrobial therapy. Early HIV diagnosis is needed to prevent NTM disease.
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