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Redox Effects of Molecular Hydrogen and Its Therapeutic Efficacy in the Treatment of Neurodegenerative Diseases

1
Department of Environmental Medical Biology, Wonju College of Medicine, Yonsei University, Wonju 26426, Gangwon-do, Korea
2
Department of Global Medical Science, Yonsei University Wonju College of Medicine, Yonsei University, Wonju 26426, Gangwon-do, Korea
*
Author to whom correspondence should be addressed.
Academic Editors: Alessandro Trentini and Biraja Dash
Processes 2021, 9(2), 308; https://doi.org/10.3390/pr9020308
Received: 9 December 2020 / Revised: 18 January 2021 / Accepted: 3 February 2021 / Published: 6 February 2021
(This article belongs to the Special Issue Advances of Redox Status in Disease)
Oxidative stress (OS) and neuroinflammatory stress affect many neurological disorders. Despite the clinical significance of oxidative damage in neurological disorders, still, no effective and safe treatment methods for neuro diseases are available. With this, molecular hydrogen (H2) has been recently reported as an antioxidant and anti-inflammatory agent to treat several oxidative stress-related diseases. In animal and human clinical trials, the routes for H2 administration are mainly categorized into three types: H2 gas inhalation, H2 water dissolving, and H2-dissolved saline injection. This review explores some significant progress in research on H2 use in neurodegenerative diseases (NDs), including Alzheimer’s disease, Parkinson’s disease, neonatal disorders of the brain, and other NDs (retinal ischemia and traumatic brain injury). Even though most neurological problems are not currently curable, these studies have shown the therapeutic potential for prevention, treatment, and mitigation of H2 administration. Several possible H2-effectors, including cell signaling molecules and hormones, which prevent OS and inflammation, will also be addressed. However, more clinical and other related studies are required to evaluate the direct H2 target molecule. View Full-Text
Keywords: molecular hydrogen; inflammation; neuroprotection; neurological disorder; oxidative stress; antioxidant molecular hydrogen; inflammation; neuroprotection; neurological disorder; oxidative stress; antioxidant
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MDPI and ACS Style

Rahman, M.H.; Bajgai, J.; Fadriquela, A.; Sharma, S.; Trinh Thi, T.; Akter, R.; Goh, S.H.; Kim, C.-S.; Lee, K.-J. Redox Effects of Molecular Hydrogen and Its Therapeutic Efficacy in the Treatment of Neurodegenerative Diseases. Processes 2021, 9, 308. https://doi.org/10.3390/pr9020308

AMA Style

Rahman MH, Bajgai J, Fadriquela A, Sharma S, Trinh Thi T, Akter R, Goh SH, Kim C-S, Lee K-J. Redox Effects of Molecular Hydrogen and Its Therapeutic Efficacy in the Treatment of Neurodegenerative Diseases. Processes. 2021; 9(2):308. https://doi.org/10.3390/pr9020308

Chicago/Turabian Style

Rahman, Md. H., Johny Bajgai, Ailyn Fadriquela, Subham Sharma, Thuy Trinh Thi, Rokeya Akter, Seong H. Goh, Cheol-Su Kim, and Kyu-Jae Lee. 2021. "Redox Effects of Molecular Hydrogen and Its Therapeutic Efficacy in the Treatment of Neurodegenerative Diseases" Processes 9, no. 2: 308. https://doi.org/10.3390/pr9020308

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