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Open AccessArticle

Field-Amplified Sample Injection-Micellar Electrokinetic Chromatography for the Determination of Benzophenones in Food Simulants

1
Department of Analytical Chemistry, University of Barcelona, Martí i Franquès 1-11, E08028 Barcelona, Spain
2
Serra Húnter Program, Generalitat de Catalunya, Rambla de Catalunya 19-21, E08007 Barcelona, Spain
*
Author to whom correspondence should be addressed.
Academic Editor: Timothy G. Strein
Chromatography 2015, 2(3), 452-471; https://doi.org/10.3390/chromatography2030452
Received: 15 June 2015 / Revised: 13 July 2015 / Accepted: 14 July 2015 / Published: 20 July 2015
(This article belongs to the Special Issue Electrophoretic Analyses in Capillaries and Microfluidic Devices)
A field-amplified sample injection-micellar electrokinetic chromatography (FASI-MEKC) method for the determination of 14 benzophenones (BPs) in a food simulant used in migration studies of food packaging materials was developed, allowing almost baseline separation in less than 21 min. The use of a 10 mM sodium dodecyl sulfate (SDS) solution as sample matrix was mandatory to achieve FASI enhancement of the analyzed BPs. A 21- to 784-fold sensitivity enhancement was achieved with FASI-MEKC, obtaining limits of detection down to 5.1–68.4 µg/L, with acceptable run-to-run precisions (RSD values lower than 22.3%) and accuracy (relative errors lower than 21.0%). Method performance was evaluated by quantifying BPs in the food simulant spiked at 500 µg/L (bellow the established specific migration limit for BP (600 µg/L) by EU legislation). For a 95% confidence level, no statistical differences were observed between found and spiked concentrations (probability at the confidence level, p value, of 0.55), showing that the proposed FASI-MEKC method is suitable for the analysis of BPs in food packaging migration studies at the levels established by EU legislation. View Full-Text
Keywords: field-amplified sample injection; micellar electrokinetic chromatography; benzophenones; migration studies; food simulants field-amplified sample injection; micellar electrokinetic chromatography; benzophenones; migration studies; food simulants
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MDPI and ACS Style

Félez, C.; Molet, A.; Núñez, O. Field-Amplified Sample Injection-Micellar Electrokinetic Chromatography for the Determination of Benzophenones in Food Simulants. Chromatography 2015, 2, 452-471.

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