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Open AccessArticle

An Improved Model for the Steric-Entropic Effect on the Retention of Rod-like Particles in Field-Flow Fractionation: Discussion of Aspect Ratio-Based Separation

Department of Chemical & Biochemical Engineering, Missouri University of Science and Technology, Rolla, MO 65409, USA
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Academic Editor: Ronald Beckett
Chromatography 2015, 2(3), 472-487; https://doi.org/10.3390/chromatography2030472
Received: 29 April 2015 / Revised: 21 July 2015 / Accepted: 22 July 2015 / Published: 28 July 2015
(This article belongs to the Special Issue Field-Flow Fractionation)
We developed an improved model for predicting the steric-entropic effect on the separation behaviors of rod-like particles in flow field-flow fractionation. Our new model incorporates the “pole-vault” rotation of a rod-like particle near a wall under shear flow into the original model developed by Beckett and Giddings which considered only Brownian rotation. We investigated the effect of the aspect ratio on the retention ratios and the cross-sectional concentration distribution in the separation of rods in field-flow fractionation (FFF). Our analyses involved comparing the results predicted using the original model and those from the new model under various rod geometries and flow conditions. We found that the new model can show the aspect ratio-enhanced elution trend in certain flow conditions for the assumption of non-constant cloud thickness (ratio between the cross flow rate and the rod diffusivity). We also deducted that the flow conditions allowing for the aspect ratio-enhanced elution are related to the interplay among the axial flow rate, cloud thickness, and rod geometry. The new model can be viewed as a prototype to qualitatively show the aspect ratio-enhanced trend since its quantitative agreement with the experimental data must be improved for our future work. View Full-Text
Keywords: field-flow fractionation; steric-entropic mode; rod-like particle; shape-based particle separation field-flow fractionation; steric-entropic mode; rod-like particle; shape-based particle separation
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Park, J.; Mittal, A. An Improved Model for the Steric-Entropic Effect on the Retention of Rod-like Particles in Field-Flow Fractionation: Discussion of Aspect Ratio-Based Separation. Chromatography 2015, 2, 472-487.

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