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From the first issue of 2016, Chromatography has changed its name to Separations.

Open AccessReview
Chromatography 2015, 2(1), 79-95;

Recent Advances and Uses of Monolithic Columns for the Analysis of Residues and Contaminants in Food

Department of Analytical Chemistry, Nutrition and Bromatology, Faculty of Veterinary Science, University of Santiago de Compostela, 27002 Lugo, Spain
These authors contributed equally to this work.
Author to whom correspondence should be addressed.
Academic Editor: Zuzana Zajickova
Received: 1 January 2015 / Accepted: 4 February 2015 / Published: 10 February 2015
(This article belongs to the Special Issue Monolithic Columns in Separation Sciences)
Full-Text   |   PDF [696 KB, uploaded 10 February 2015]


Monolithic columns are gaining interest as excellent substitutes to conventional particle-packed columns. These columns show higher permeability and lower flow resistance than conventional liquid chromatography columns, providing high-throughput performance, resolution and separation in short run times. Monoliths possess also great potential for the clean-up and preparation of complex mixtures. In situ polymerization inside appropriate supports allows the development of several microextraction formats, such as in-tube solid-phase and pipette tip-based extractions. These techniques using porous monoliths offer several advantages, including miniaturization and on-line coupling with analytical instruments. Additionally, monoliths are ideal support media for imprinting template-specific sites, resulting in the so-called molecularly-imprinted monoliths, with ultra-high selectivity. In this review, time-saving LC columns and preparative applications applied to the analysis of residues and contaminants in food in 2010–2014 are described, focusing on recent improvements in design and with emphasis in automated on-line systems and innovative materials and formats. View Full-Text
Keywords: monolith; solid-phase; MIP; chromatography; food; residues; contaminants monolith; solid-phase; MIP; chromatography; food; residues; contaminants
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Díaz-Bao, M.; Barreiro, R.; Miranda, J.M.; Cepeda, A.; Regal, P. Recent Advances and Uses of Monolithic Columns for the Analysis of Residues and Contaminants in Food. Chromatography 2015, 2, 79-95.

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