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Review

Pediatric Tuberculosis Management: A Global Challenge or Breakthrough?

by
Lehlogonolo N. F. Maphalle
1,
Bozena B. Michniak-Kohn
2,3,
Modupe O. Ogunrombi
4 and
Oluwatoyin A. Adeleke
1,5,6,*,†
1
Division of Pharmaceutical Sciences, School of Pharmacy, Sefako Makgatho Health Sciences University, Pretoria 0208, South Africa
2
Ernest Mario School of Pharmacy, Rutgers-The State University of New Jersey, 160 Frelinghuysen Road, Piscataway, NJ 08854, USA
3
Center for Dermal Research, Rutgers-The State University of New Jersey, 145 Bevier Road, Piscataway, NJ 08854, USA
4
Department of Clinical Pharmacology and Therapeutics, Sefako Makgatho Health Science University, Pretoria 0208, South Africa
5
Department of Pharmaceutical Sciences, College of Pharmacy, Howard University, 2300 4th Street NW, Washington, DC 20059, USA
6
Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institute of Health, Bethesda, MD 20892, USA
*
Author to whom correspondence should be addressed.
Current address: Faculty of Health, College of Pharmacy, Dalhousie University, Halifax, NS B3H 4R2, Canada.
Children 2022, 9(8), 1120; https://doi.org/10.3390/children9081120
Submission received: 17 June 2022 / Revised: 19 July 2022 / Accepted: 23 July 2022 / Published: 27 July 2022
(This article belongs to the Section Pediatric Infectious Diseases)

Abstract

Managing pediatric tuberculosis (TB) remains a public health problem requiring urgent and long-lasting solutions as TB is one of the top ten causes of ill health and death in children as well as adolescents universally. Minors are particularly susceptible to this severe illness that can be fatal post-infection or even serve as reservoirs for future disease outbreaks. However, pediatric TB is the least prioritized in most health programs and optimal infection/disease control has been quite neglected for this specialized patient category, as most scientific and clinical research efforts focus on developing novel management strategies for adults. Moreover, the ongoing coronavirus pandemic has meaningfully hindered the gains and progress achieved with TB prophylaxis, therapy, diagnosis, and global eradication goals for all affected persons of varying age bands. Thus, the opening of novel research activities and opportunities that can provide more insight and create new knowledge specifically geared towards managing TB disease in this specialized group will significantly improve their well-being and longevity.
Keywords: pediatrics; pulmonary tuberculosis; extrapulmonary tuberculosis; diagnosis; treatment; prevention; coronavirus pandemic; COVID-19 pediatrics; pulmonary tuberculosis; extrapulmonary tuberculosis; diagnosis; treatment; prevention; coronavirus pandemic; COVID-19

Share and Cite

MDPI and ACS Style

Maphalle, L.N.F.; Michniak-Kohn, B.B.; Ogunrombi, M.O.; Adeleke, O.A. Pediatric Tuberculosis Management: A Global Challenge or Breakthrough? Children 2022, 9, 1120. https://doi.org/10.3390/children9081120

AMA Style

Maphalle LNF, Michniak-Kohn BB, Ogunrombi MO, Adeleke OA. Pediatric Tuberculosis Management: A Global Challenge or Breakthrough? Children. 2022; 9(8):1120. https://doi.org/10.3390/children9081120

Chicago/Turabian Style

Maphalle, Lehlogonolo N. F., Bozena B. Michniak-Kohn, Modupe O. Ogunrombi, and Oluwatoyin A. Adeleke. 2022. "Pediatric Tuberculosis Management: A Global Challenge or Breakthrough?" Children 9, no. 8: 1120. https://doi.org/10.3390/children9081120

APA Style

Maphalle, L. N. F., Michniak-Kohn, B. B., Ogunrombi, M. O., & Adeleke, O. A. (2022). Pediatric Tuberculosis Management: A Global Challenge or Breakthrough? Children, 9(8), 1120. https://doi.org/10.3390/children9081120

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