Distinctive Phenotype of Multisystem Inflammatory Syndrome in Children Associated with SARS-CoV-2 According to Patients’ Age: A Monocentric Experience
Abstract
:1. Introduction
2. Materials and Methods
3. Results
3.1. Characteristics of Patients with MIS-C
3.2. Difference According to Age Groups
3.3. Severity of Presentation
4. Discussion
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Variables | Value |
---|---|
Males + | 18 (51%) |
Age in years * | 7 (4–10) |
Underlying medical conditions (excluding obesity) + | 1 (3%) ** |
Obesity + | 7 (20%) |
Duration of symptoms before hospital admission in days * | 3 (3–5) |
Clinical presentation: | |
| 35 (100%) |
| 24 (69%) |
| 17 (49%) |
| 12 (34%) |
| 17 (49%) |
| 3 (9%) |
| 21 (60%) |
| 17 (49%) |
| 5 (14%) |
Length of hospitalization in days * | 12 (8–15) |
Laboratory values: * | |
| 11.7 (7.9–15.7) |
| 1.2 (1.0–2.1) |
| 206 (162–252) |
| 145 (106–211) |
| 2.4 (0.7–11.2) |
| 8.3 (5.1–17.2) |
| 567 (414–748) |
| 1084 (806–1844) |
| 35 (21–58) |
| 28 (16–54) |
| 35 (25–51) |
| 3.4 (3.3–3.7) |
| 2.8 (2.1–3.7) |
| 460 (361–567) |
| 21 (8–51) |
| 125 (58–745) |
| 4031 (2197–8772) |
| 45 (11–159) |
Abnormal findings in imaging: + | |
| 28 (80%) |
| 31 (89%) |
| 26 (74%) |
Number of organs/systems involved: + | |
| 1 (3%) |
| 6 (17%) |
| 28 (80%) |
Medications for MIS-C: + | |
| 32 (91%) |
| 31 (89%) |
| 17 (49%) |
| 29 (83%) |
| 5 (14%) |
| 1 (3%) |
| 10 (29%) |
| 21 (60%) |
Parameters | Group 1: ≤5 Years (n = 13) | Group 2: >5 Years (n = 22) | p |
---|---|---|---|
Males + | 8 (62%) | 10 (45%) | ns |
Obesity + | 0 | 6 (27%) | ns |
Clinical presentation: + | |||
| 13 (100%) | 22 (100%) | |
| 11 (85%) | 13 (59%) | ns |
| 9 (69%) | 8 (36%) | ns |
| 4 (31%) | 8 (36%) | ns |
| 8 (62%) | 9 (41%) | ns |
| 1 (8%) | 2 (9%) | ns |
| 4 (31%) | 17 (77%) | 0.01 |
| 5 (38%) | 12 (55%) | ns |
| 6 (46%) | 6 (27%) | ns |
Length of hospitalization in days * | 8 (6–10) | 13 (12–16) | 0.04 |
Laboratory values: * | |||
| 13.1 (11.7–15.8) | 10.2 (7.9–15.5) | ns |
| 2.2 (1.9–3.2) | 1.0 (0.8–1.3) | <0.01 |
| 225 (170–252) | 198 (151–242) | ns |
| 144 (115–179) | 146 (83–216) | ns |
| 1.4 (0.7–10.9) | 2.4 (0.8–11.2) | ns |
| 7.9 (5.0–11.6) | 9.3 (6.4–19.4) | |
| 529 (399–720) | 597 (461–765) | ns |
| 928 (658–1636) | 1116 (883–1844) | ns |
| 28 (21–51) | 38 (20–58) | ns |
| 18 (15–50) | 31 (17–54) | ns |
| 30 (22–37) | 42 (27–58) | ns |
| 3.4 (3.0–3.7) | 3.4 (3.0–3.7) | ns |
| 515 (495–570) | 395 (345–542) | ns |
| 9 (5–13) | 27 (21–53) | <0.01 |
| 151 (75–620) | 123 (57–745) | ns |
| 6148 (2728–9681) | 4031 (1258–9681) | ns |
| 122 (102–297) | 29 (8–70) | ns |
Abnormal findings in imaging: + | |||
| 8 (67%) | 20 (91%) | 0.07 |
| 11 (85%) | 20 (91%) | ns |
| 8 (62%) | 18 (82%) | ns |
Number of organs/systems involved: + | |||
| 0 | 1 (5%) | |
| 2 (15%) | 4 (18%) | ns |
| 11 (85%) | 17 (77%) | |
Medications for MIS-C: + | |||
| 12 (92%) | 20 (91%) | ns |
| 11 (85%) | 20 (91%) | ns |
| 3 (23%) | 14 (64%) | 0.04 |
| 9 (69%) | 20 (91%) | ns |
| 0 | 5 (23%) | ns |
| 1 (8%) | 0 | ns |
| 2 (15%) | 8 (36%) | ns |
| 8 (62%) | 13 (59%) | ns |
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Giannattasio, A.; Orlando, F.; D’Anna, C.; Muzzica, S.; Angrisani, F.; Acierno, S.; Paciello, F.; Savoia, F.; Tardi, M.; Mauro, A.; et al. Distinctive Phenotype of Multisystem Inflammatory Syndrome in Children Associated with SARS-CoV-2 According to Patients’ Age: A Monocentric Experience. Children 2022, 9, 468. https://doi.org/10.3390/children9040468
Giannattasio A, Orlando F, D’Anna C, Muzzica S, Angrisani F, Acierno S, Paciello F, Savoia F, Tardi M, Mauro A, et al. Distinctive Phenotype of Multisystem Inflammatory Syndrome in Children Associated with SARS-CoV-2 According to Patients’ Age: A Monocentric Experience. Children. 2022; 9(4):468. https://doi.org/10.3390/children9040468
Chicago/Turabian StyleGiannattasio, Antonietta, Francesca Orlando, Carolina D’Anna, Stefania Muzzica, Francesca Angrisani, Sabrina Acierno, Francesca Paciello, Fabio Savoia, Maria Tardi, Angela Mauro, and et al. 2022. "Distinctive Phenotype of Multisystem Inflammatory Syndrome in Children Associated with SARS-CoV-2 According to Patients’ Age: A Monocentric Experience" Children 9, no. 4: 468. https://doi.org/10.3390/children9040468