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Distinctive Phenotype of Multisystem Inflammatory Syndrome in Children Associated with SARS-CoV-2 According to Patients’ Age: A Monocentric Experience
 
 
Article

Liver and Pancreatic Involvement in Children with Multisystem Inflammatory Syndrome Related to SARS-CoV-2: A Monocentric Study

1
Pediatric Emergency Unit, Santobono-Pausilipon Children’s Hospital, AORN, 80130 Naples, Italy
2
Medical Department, University of Salerno, 84084 Salerno, Italy
*
Author to whom correspondence should be addressed.
Academic Editor: Bibhuti B. Das
Children 2022, 9(4), 575; https://doi.org/10.3390/children9040575
Received: 19 March 2022 / Revised: 11 April 2022 / Accepted: 15 April 2022 / Published: 18 April 2022
(This article belongs to the Special Issue Progress on Pediatric Inflammatory Multisystem Syndrome)
Liver and pancreatic involvement in children with Multisystem Inflammatory Syndrome related to SARS-CoV-2 (MIS-C) has been poorly investigated so far. We reviewed a cohort of MIS-C patients to analyze the prevalence of acute liver injury (ALI) and pancreatic injury and their correlation with clinical outcomes. Demographic, clinical, laboratory and imaging features of children with MIS-C at admission and during hospital stay were prospectively collected. Fifty-five patients (mean age 6.5 ± 3.7 years) were included. At admission, 16 patients showed ALI and 5 had increased total serum lipase. During observation, 10 more patients developed ALI and 19 more subjects presented raised pancreatic enzymes. In comparison to those with normal ALT, subjects with ALI were significantly older (p = 0.0004), whereas pancreatic involvement was associated to a longer duration of hospital stay compared with patients with normal pancreatic enzymes (p = 0.004). Time between hospital admission and onset of ALI was shorter compared to the onset of raised pancreatic enzymes (3.2 ± 3.9 versus 5.3 ± 2.7 days, respectively; p = 0.035). Abdominal ultrasound showed liver steatosis in 3/26 (12%) and hepatomegaly in 6/26 (16%) patients with ALI; 2 patients presented enlarged pancreas. Although liver and pancreatic involvement is commonly observed in MIS-C patients, it is mild in most cases with a complete recovery. View Full-Text
Keywords: multisystem inflammatory syndrome related to SARS-CoV-2; children; acute liver injury; pancreatic injury; prognosis multisystem inflammatory syndrome related to SARS-CoV-2; children; acute liver injury; pancreatic injury; prognosis
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MDPI and ACS Style

Giannattasio, A.; Maglione, M.; D’Anna, C.; Muzzica, S.; Pappacoda, S.; Lenta, S.; Di Mita, O.; Ranucci, G.; Mandato, C.; Tipo, V. Liver and Pancreatic Involvement in Children with Multisystem Inflammatory Syndrome Related to SARS-CoV-2: A Monocentric Study. Children 2022, 9, 575. https://doi.org/10.3390/children9040575

AMA Style

Giannattasio A, Maglione M, D’Anna C, Muzzica S, Pappacoda S, Lenta S, Di Mita O, Ranucci G, Mandato C, Tipo V. Liver and Pancreatic Involvement in Children with Multisystem Inflammatory Syndrome Related to SARS-CoV-2: A Monocentric Study. Children. 2022; 9(4):575. https://doi.org/10.3390/children9040575

Chicago/Turabian Style

Giannattasio, Antonietta, Marco Maglione, Carolina D’Anna, Stefania Muzzica, Serena Pappacoda, Selvaggia Lenta, Onorina Di Mita, Giusy Ranucci, Claudia Mandato, and Vincenzo Tipo. 2022. "Liver and Pancreatic Involvement in Children with Multisystem Inflammatory Syndrome Related to SARS-CoV-2: A Monocentric Study" Children 9, no. 4: 575. https://doi.org/10.3390/children9040575

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