Next Article in Journal
An Overview on Acute Malnutrition and Food Insecurity among Children during the Conflict in Yemen
Previous Article in Journal
Children’s Physical Activity Levels Following Participation in a Classroom-Based Physical Activity Curriculum
Previous Article in Special Issue
Long-Term Treatment Strategies of Pediatric Multiple Sclerosis, Including the use of Disease Modifying Therapies

Differential Diagnosis of Pediatric Multiple Sclerosis

Department of Neurology, Washington University in St. Louis, St. Louis, MO 63110, USA
Author to whom correspondence should be addressed.
Children 2019, 6(6), 75;
Received: 19 April 2019 / Revised: 16 May 2019 / Accepted: 20 May 2019 / Published: 3 June 2019
(This article belongs to the Special Issue Multiple Sclerosis and Demyelinating Disorders in Children)
The differential diagnosis of pediatric multiple sclerosis (MS) can be broad and pose diagnostic challenges, particularly at initial presentation. Among demyelinating entities, neuromyelitis optica spectrum disorders (NMOSD), myelin oligodendrocyte glycoprotein antibodies (MOG-ab) associated disorders, and acute disseminated encephalomyelitis (ADEM) are now well-known as unique disease processes and yet continue to overlap with MS in regards to clinical presentation and imaging. In non-inflammatory entities, such as metabolic disorders and leukodystrophies, an erroneous diagnosis of MS can be made even while applying appropriate diagnostic criteria. Knowing the epidemiology, typical clinical presentation, diagnostic criteria, and ancillary test results in each disease, can aid in making the correct diagnosis by contrasting these features with those of pediatric MS. Determining the correct diagnosis early, allows for efficient and effective treatment as well as appropriate prognostication. View Full-Text
Keywords: demyelination; pediatric multiple sclerosis; NMOSD; MOG-ab; ADEM; leukodystrophies; metabolic disorders demyelination; pediatric multiple sclerosis; NMOSD; MOG-ab; ADEM; leukodystrophies; metabolic disorders
Show Figures

Figure 1

MDPI and ACS Style

Galardi, M.M.; Gaudioso, C.; Ahmadi, S.; Evans, E.; Gilbert, L.; Mar, S. Differential Diagnosis of Pediatric Multiple Sclerosis. Children 2019, 6, 75.

AMA Style

Galardi MM, Gaudioso C, Ahmadi S, Evans E, Gilbert L, Mar S. Differential Diagnosis of Pediatric Multiple Sclerosis. Children. 2019; 6(6):75.

Chicago/Turabian Style

Galardi, Maria Milagros, Cristina Gaudioso, Saumel Ahmadi, Emily Evans, Laura Gilbert, and Soe Mar. 2019. "Differential Diagnosis of Pediatric Multiple Sclerosis" Children 6, no. 6: 75.

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

Back to TopTop