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Open AccessArticle

Pathophysiology of Atopic Dermatitis and Psoriasis: Implications for Management in Children

1
Department of Dermatology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
2
Department of Dermatology, George Washington University School of Medicine, Washington, DC 20037, USA
*
Author to whom correspondence should be addressed.
Children 2019, 6(10), 108; https://doi.org/10.3390/children6100108
Received: 30 August 2019 / Revised: 23 September 2019 / Accepted: 25 September 2019 / Published: 4 October 2019
(This article belongs to the Special Issue Atopic Dermatitis and Psoriasis in Children)
Atopic dermatitis (AD) and psoriasis are chronic inflammatory skin diseases associated with a significant cutaneous and systemic burden of disease as well as a poor health-related quality of life. Here, we review the complex pathophysiology of both AD and psoriasis and discuss the implications for treatment with current state-of-the-art and emerging topical and systemic therapies. Both AD and psoriasis are caused by a complex combination of immune dysregulation, skin-barrier disruption, genetic factors, and environmental influences. Previous treatments for both diseases were limited to anti-inflammatory agents that broadly suppress inflammation. Emerging insights into relevant pathways, including recognition of the role of T-helper type 2 driven inflammation in AD and T-helper 1 and 17 driven inflammation in psoriasis, have led to a therapeutic revolution. There are a number of novel treatment options available for AD and psoriasis with many more currently under investigation. View Full-Text
Keywords: atopic dermatitis; psoriasis; inflammation; cytokine; skin-barrier; topical therapy; systemic therapy; biologic therapy atopic dermatitis; psoriasis; inflammation; cytokine; skin-barrier; topical therapy; systemic therapy; biologic therapy
MDPI and ACS Style

Chovatiya, R.; Silverberg, J.I. Pathophysiology of Atopic Dermatitis and Psoriasis: Implications for Management in Children. Children 2019, 6, 108.

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