Next Article in Journal
Parenting in the Context of Children’s Chronic Pain: Balancing Care and Burden
Next Article in Special Issue
Pediatric Fatty Liver and Obesity: Not Always Just a Matter of Non-Alcoholic Fatty Liver Disease
Previous Article in Journal
Exploring the Effect of Perceptions on Children’s Physical Activity in Varying Geographic Contexts: Using a Structural Equation Modelling Approach to Examine a Cross-Sectional Dataset
Previous Article in Special Issue
Extracellular Vesicles: A Potential Novel Regulator of Obesity and Its Associated Complications
Article Menu
Issue 12 (December) cover image

Export Article

Open AccessReview
Children 2018, 5(12), 160;

Development of the Gut Microbiome in Children, and Lifetime Implications for Obesity and Cardiometabolic Disease

Division of Cardiovascular Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA
Division of Critical Care Medicine, Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232, USA
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Received: 23 October 2018 / Revised: 19 November 2018 / Accepted: 22 November 2018 / Published: 27 November 2018
(This article belongs to the Special Issue Obesity and Metabolic Dysregulation in Childhood)
PDF [704 KB, uploaded 29 November 2018]


Emerging evidence suggests that microbiome composition and function is associated with development of obesity and metabolic disease. Microbial colonization expands rapidly following birth, and microbiome composition is particularly variable during infancy. Factors that influence the formation of the gut microbiome during infancy and childhood may have a significant impact on development of obesity and metabolic dysfunction, with life-long consequences. In this review, we examine the determinants of gut microbiome composition during infancy and childhood, and evaluate the potential impact on obesity and cardiometabolic risk. View Full-Text
Keywords: microbiome; obesity; cardiometabolic disease microbiome; obesity; cardiometabolic disease

Graphical abstract

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Share & Cite This Article

MDPI and ACS Style

Mohammadkhah, A.I.; Simpson, E.B.; Patterson, S.G.; Ferguson, J.F. Development of the Gut Microbiome in Children, and Lifetime Implications for Obesity and Cardiometabolic Disease. Children 2018, 5, 160.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Children EISSN 2227-9067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top