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Children 2018, 5(12), 160; https://doi.org/10.3390/children5120160

Development of the Gut Microbiome in Children, and Lifetime Implications for Obesity and Cardiometabolic Disease

1
Division of Cardiovascular Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA
2
Division of Critical Care Medicine, Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232, USA
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Received: 23 October 2018 / Revised: 19 November 2018 / Accepted: 22 November 2018 / Published: 27 November 2018
(This article belongs to the Special Issue Obesity and Metabolic Dysregulation in Childhood)
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Abstract

Emerging evidence suggests that microbiome composition and function is associated with development of obesity and metabolic disease. Microbial colonization expands rapidly following birth, and microbiome composition is particularly variable during infancy. Factors that influence the formation of the gut microbiome during infancy and childhood may have a significant impact on development of obesity and metabolic dysfunction, with life-long consequences. In this review, we examine the determinants of gut microbiome composition during infancy and childhood, and evaluate the potential impact on obesity and cardiometabolic risk. View Full-Text
Keywords: microbiome; obesity; cardiometabolic disease microbiome; obesity; cardiometabolic disease
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Mohammadkhah, A.I.; Simpson, E.B.; Patterson, S.G.; Ferguson, J.F. Development of the Gut Microbiome in Children, and Lifetime Implications for Obesity and Cardiometabolic Disease. Children 2018, 5, 160.

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