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Children 2018, 5(11), 152; https://doi.org/10.3390/children5110152

Extracellular Vesicles: A Potential Novel Regulator of Obesity and Its Associated Complications

1,2, 1,2,* and 1,2,*
1
Division of Endocrinology, Cincinnati Children’s Hospital Medical Center, 3333 Burnet Ave., Cincinnati, OH 45229, USA
2
Department of Pediatrics, University of Cincinnati College of Medicine, 3333 Burnet Ave., Cincinnati, OH 45229, USA
*
Authors to whom correspondence should be addressed.
Received: 14 September 2018 / Revised: 9 November 2018 / Accepted: 9 November 2018 / Published: 15 November 2018
(This article belongs to the Special Issue Obesity and Metabolic Dysregulation in Childhood)
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PDF [508 KB, uploaded 15 November 2018]
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Abstract

Childhood obesity continues to be a major public health concern. Obesity causes various metabolic complications, including insulin resistance, type 2 diabetes mellitus (T2DM), non-alcoholic fatty liver disease (NAFLD), dyslipidemia, and cardiovascular disease. However, currently, we have a limited understanding of the pathophysiology in the development of these processes. Extracellular vesicles (EVs) are nano-sized vesicles secreted by different cell types that travel to various organ systems carrying molecular and genetic information. These vesicles have been proposed as a novel intercellular communication mode in systemic metabolic regulation and in several pathophysiologic processes. In particular, recent studies indicate that EVs play a critical role in the pathogenesis of obesity and its metabolic complications. In this study, we reviewed the current literature that supports the role of EVs in the regulation of metabolic homeostasis and pathogenesis of obesity and its associated metabolic complications, with a short discussion about future directions in the EV research field. View Full-Text
Keywords: type 2 diabetes; obesity; extracellular vesicles; exosomes; pediatrics type 2 diabetes; obesity; extracellular vesicles; exosomes; pediatrics
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Kim, A.; Shah, A.S.; Nakamura, T. Extracellular Vesicles: A Potential Novel Regulator of Obesity and Its Associated Complications. Children 2018, 5, 152.

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