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Review

Biologic Therapy and Severe Asthma in Children

1
Department of Pediatrics, University of Chieti, 66100 Chieti, Italy
2
Pediatric Allergy and Respiratory Unit, Department of Pediatrics, University of Chieti, 66100 Chieti, Italy
*
Author to whom correspondence should be addressed.
Academic Editor: Girolamo Pelaia
Biomedicines 2021, 9(7), 760; https://doi.org/10.3390/biomedicines9070760
Received: 15 June 2021 / Revised: 23 June 2021 / Accepted: 24 June 2021 / Published: 30 June 2021
(This article belongs to the Special Issue Molecular Targets for Biological Therapies of Severe Asthma)
Severe asthma is a heterogeneous, complex and chronic disease widespread in the pediatric population. According to the recent findings about the different endotypes of asthma in children, each one characterized by specific intracellular molecular pathways, several innovative biologic therapies have been developed. Due to their precise ability to target specific inflammatory type 2 mediators, biologics have revolutionized the care of chronic allergic diseases in the pediatric and adult population. In this review, we aim to provide the latest evidence about the use, indications, efficacy and safety of biologic therapies to treat severe asthma in children and adolescents. View Full-Text
Keywords: severe asthma; children; biologic therapy; endotype; phenotype severe asthma; children; biologic therapy; endotype; phenotype
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MDPI and ACS Style

Russo, D.; Di Filippo, P.; Attanasi, M.; Lizzi, M.; Di Pillo, S.; Chiarelli, F. Biologic Therapy and Severe Asthma in Children. Biomedicines 2021, 9, 760. https://doi.org/10.3390/biomedicines9070760

AMA Style

Russo D, Di Filippo P, Attanasi M, Lizzi M, Di Pillo S, Chiarelli F. Biologic Therapy and Severe Asthma in Children. Biomedicines. 2021; 9(7):760. https://doi.org/10.3390/biomedicines9070760

Chicago/Turabian Style

Russo, Daniele, Paola Di Filippo, Marina Attanasi, Mauro Lizzi, Sabrina Di Pillo, and Francesco Chiarelli. 2021. "Biologic Therapy and Severe Asthma in Children" Biomedicines 9, no. 7: 760. https://doi.org/10.3390/biomedicines9070760

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