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Involvement of microRNA in Solid Cancer: Role and Regulatory Mechanisms
Review

MicroRNAs Regulating Hippo-YAP Signaling in Liver Cancer

by 1,2, 1,2 and 1,2,3,*
1
Institute of Tissue Regeneration Engineering (ITREN), Dankook University, Cheonan 31116, Korea
2
Department of Nanobiomedical Science and BK21 PLUS NBM Global Research Center for Regenerative Medicine, Dankook University, Cheonan 31116, Korea
3
Department of Regenerative Dental Medicine, College of Dentistry, Dankook University, Cheonan 31116, Korea
*
Author to whom correspondence should be addressed.
Academic Editor: Francesca Lovat
Biomedicines 2021, 9(4), 347; https://doi.org/10.3390/biomedicines9040347
Received: 9 March 2021 / Revised: 23 March 2021 / Accepted: 25 March 2021 / Published: 30 March 2021
(This article belongs to the Special Issue MicroRNA in Solid Tumor and Hematological Diseases)
Liver cancer is one of the most common cancers worldwide, and its prevalence and mortality rate are increasing due to the lack of biomarkers and effective treatments. The Hippo signaling pathway has long been known to control liver size, and genetic depletion of Hippo kinases leads to liver cancer in mice through activation of the downstream effectors yes-associated protein (YAP) and transcriptional coactivator with PDZ-binding motif (TAZ). Both YAP and TAZ not only reprogram tumor cells but also alter the tumor microenvironment to exert carcinogenic effects. Therefore, understanding the mechanisms of YAP/TAZ-mediated liver tumorigenesis will help overcome liver cancer. For decades, small noncoding RNAs, microRNAs (miRNAs), have been reported to play critical roles in the pathogenesis of many cancers, including liver cancer. However, the interactions between miRNAs and Hippo-YAP/TAZ signaling in the liver are still largely unknown. Here, we review miRNAs that influence the proliferation, migration and apoptosis of tumor cells by modulating Hippo-YAP/TAZ signaling during hepatic tumorigenesis. Previous findings suggest that these miRNAs are potential biomarkers and therapeutic targets for the diagnosis, prognosis, and treatment of liver cancer. View Full-Text
Keywords: microRNAs; hepatocellular carcinoma; Hippo kinase; Yes-associated protein; liver disease; diagnosis; prognosis; cancer therapy microRNAs; hepatocellular carcinoma; Hippo kinase; Yes-associated protein; liver disease; diagnosis; prognosis; cancer therapy
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MDPI and ACS Style

Lee, N.-H.; Kim, S.J.; Hyun, J. MicroRNAs Regulating Hippo-YAP Signaling in Liver Cancer. Biomedicines 2021, 9, 347. https://doi.org/10.3390/biomedicines9040347

AMA Style

Lee N-H, Kim SJ, Hyun J. MicroRNAs Regulating Hippo-YAP Signaling in Liver Cancer. Biomedicines. 2021; 9(4):347. https://doi.org/10.3390/biomedicines9040347

Chicago/Turabian Style

Lee, Na-Hyun, So J. Kim, and Jeongeun Hyun. 2021. "MicroRNAs Regulating Hippo-YAP Signaling in Liver Cancer" Biomedicines 9, no. 4: 347. https://doi.org/10.3390/biomedicines9040347

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