Curcumin as Scaffold for Drug Discovery against Neurodegenerative Diseases
1
Mitchell Center for Neurodegenerative Diseases, University of Texas Medical Branch, Galveston, TX 77555, USA
2
Departments of Neurology, Neuroscience and Cell Biology, University of Texas Medical Branch, Galveston, TX 77555, USA
3
Department of Biological, Chemical and Pharmaceutical Sciences and Technologies-STEBICEF, University of Palermo, 90128 Palermo, Italy
*
Author to whom correspondence should be addressed.
Academic Editor: Lorenzo Falsetti
Biomedicines 2021, 9(2), 173; https://doi.org/10.3390/biomedicines9020173
Received: 11 January 2021
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Revised: 2 February 2021
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Accepted: 8 February 2021
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Published: 9 February 2021
(This article belongs to the Special Issue Molecular Research of Alzheimer's Disease)
Neurodegenerative diseases (NDs) are one of major public health problems and their impact is continuously growing. Curcumin has been proposed for the treatment of several of these pathologies, such as Alzheimer’s disease (AD) and Parkinson’s disease (PD) due to the ability of this molecule to reduce inflammation and aggregation of involved proteins. Nevertheless, the poor metabolic stability and bioavailability of curcumin reduce the possibilities of its practical use. For these reasons, many curcumin derivatives were synthetized in order to overcome some limitations. In this review will be highlighted recent results on modification of curcumin scaffold in the search of new effective therapeutic agents against NDs, with particular emphasis on AD.
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Keywords:
curcumin; Alzheimer’s disease; amyloid; tau
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MDPI and ACS Style
Lo Cascio, F.; Marzullo, P.; Kayed, R.; Palumbo Piccionello, A. Curcumin as Scaffold for Drug Discovery against Neurodegenerative Diseases. Biomedicines 2021, 9, 173. https://doi.org/10.3390/biomedicines9020173
AMA Style
Lo Cascio F, Marzullo P, Kayed R, Palumbo Piccionello A. Curcumin as Scaffold for Drug Discovery against Neurodegenerative Diseases. Biomedicines. 2021; 9(2):173. https://doi.org/10.3390/biomedicines9020173
Chicago/Turabian StyleLo Cascio, Filippa, Paola Marzullo, Rakez Kayed, and Antonio Palumbo Piccionello. 2021. "Curcumin as Scaffold for Drug Discovery against Neurodegenerative Diseases" Biomedicines 9, no. 2: 173. https://doi.org/10.3390/biomedicines9020173
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