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A Mini-Review: Clinical Development and Potential of Aptamers for Thrombotic Events Treatment and Monitoring

Department of Pharmaceutical Sciences, Nesbitt School of Pharmacy, Wilkes University, 84 W. South Street, Wilkes-Barre, PA 18766, USA
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Biomedicines 2019, 7(3), 55; https://doi.org/10.3390/biomedicines7030055
Received: 29 June 2019 / Revised: 21 July 2019 / Accepted: 24 July 2019 / Published: 26 July 2019
(This article belongs to the Special Issue Engineering Aptamers for Biomedical Applications II)
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Abstract

The unique opportunity for aptamer uses in thrombotic events has sparked a considerable amount of research in the area. The short half-lives of unmodified aptamers in vivo remain one of the major challenges in therapeutic aptamers. Much of the incremental successful therapeutic aptamer stories were due to modifications in the aptamer bases. This mini-review briefly summarizes the successes and challenges in the clinical development of aptamers for thrombotic events, and highlights some of the most recent developments in using aptamers for anticoagulation monitoring. View Full-Text
Keywords: thrombotic event; aptamer; DNA; RNA; SELEX; molecular recognition element (MRE); monitoring; treatment thrombotic event; aptamer; DNA; RNA; SELEX; molecular recognition element (MRE); monitoring; treatment
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Ponce, A.T.; Hong, K.L. A Mini-Review: Clinical Development and Potential of Aptamers for Thrombotic Events Treatment and Monitoring. Biomedicines 2019, 7, 55.

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