Next Article in Journal
Neuroprotective and Anti-Inflammatory Effects of Rhus coriaria Extract in a Mouse Model of Ischemic Optic Neuropathy
Next Article in Special Issue
Hypoxia, Metabolism and Immune Cell Function
Previous Article in Journal
Tumor Molecular Profiling for an Individualized Approach to the Treatment of Hepatocellular Carcinoma: A Patient Case Study
Previous Article in Special Issue
VHL and Hypoxia Signaling: Beyond HIF in Cancer
Open AccessReview

Hypoxia and Chromatin: A Focus on Transcriptional Repression Mechanisms

1
Department of Biochemistry, Institute of Integrative Biology, University of Liverpool, Crown Street, Liverpool L697ZB, UK
2
Department of Biochemistry, Institute of Biomedical Research, Autonomous Madrid University, Arturo Duperier, 4. 28029 Madrid, Spain
*
Author to whom correspondence should be addressed.
Biomedicines 2018, 6(2), 47; https://doi.org/10.3390/biomedicines6020047
Received: 28 February 2018 / Revised: 26 March 2018 / Accepted: 19 April 2018 / Published: 22 April 2018
(This article belongs to the Special Issue Hypoxia)
Hypoxia or reduced oxygen availability has been studied extensively for its ability to activate specific genes. Hypoxia-induced gene expression is mediated by the HIF transcription factors, but not exclusively so. Despite the extensive knowledge about how hypoxia activates genes, much less is known about how hypoxia promotes gene repression. In this review, we discuss the potential mechanisms underlying hypoxia-induced transcriptional repression responses. We highlight HIF-dependent and independent mechanisms as well as the potential roles of dioxygenases with functions at the nucleosome and DNA level. Lastly, we discuss recent evidence regarding the involvement of transcriptional repressor complexes in hypoxia. View Full-Text
Keywords: hypoxia; chromatin; transcriptional repression; repressor Complexes; JmjC; histone methylation; HIF hypoxia; chromatin; transcriptional repression; repressor Complexes; JmjC; histone methylation; HIF
Show Figures

Graphical abstract

MDPI and ACS Style

Batie, M.; Del Peso, L.; Rocha, S. Hypoxia and Chromatin: A Focus on Transcriptional Repression Mechanisms. Biomedicines 2018, 6, 47.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop