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Biomedicines 2018, 6(2), 46; https://doi.org/10.3390/biomedicines6020046

Tumor Molecular Profiling for an Individualized Approach to the Treatment of Hepatocellular Carcinoma: A Patient Case Study

1
Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
2
Department of Radiology, Penn State Health Milton S. Hershey Medical Center, Hershey, PA 17033, USA
3
Department of Pathology, Penn State Health Milton S. Hershey Medical Center, Hershey, PA 17033, USA
4
Division of Hematology-Oncology, Department of Medicine, Penn State Health Milton S. Hershey Medical Center; Experimental Therapeutics Program, Penn State Cancer Institute, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
*
Author to whom correspondence should be addressed.
Received: 13 March 2018 / Revised: 7 April 2018 / Accepted: 9 April 2018 / Published: 17 April 2018
(This article belongs to the Special Issue Cancer Biomarkers and Targets in Digestive Organs)
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Abstract

Hepatocellular carcinoma (HCC) is increasing in incidence, and the associated mortality rate remains among the highest. For advanced HCC, sorafenib has been shown to slightly prolong survival, and regorafenib and nivolumab, both recently approved by the United States Food and Drug Administration (FDA), may produce clinical benefits to a limited extent. Systemic chemotherapy has been shown to produce a modest response, but there is no clinically valid biomarker that can be used to predict which patients may benefit. In this case study, we present two patients with metastatic HCC, they received systemic treatment using capecitabine, oxaliplatin, and either bevacizumab or sorafenib. The tumor response to treatment was determined by the progression-free survival (PFS). Molecular profiling of the tumors showed differential expression of biochemical markers and different mutational status of the TP53 and β-catenin (CTNNB1) genes. We hypothesize that the PFS correlates with the tumor molecular profiles, which may be predictive of the therapeutic response to systemic chemotherapy. Further investigation is indicated to correlate tumor biomarkers and treatment responses, with the objective of personalizing the therapies for patients with advanced HCC. View Full-Text
Keywords: hepatocellular carcinoma; immunohistochemistry; molecular profiling; next-generation sequencing; precision medicine; predictive biomarkers hepatocellular carcinoma; immunohistochemistry; molecular profiling; next-generation sequencing; precision medicine; predictive biomarkers
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Posadas, K.; Ankola, A.; Yang, Z.; Yee, N.S. Tumor Molecular Profiling for an Individualized Approach to the Treatment of Hepatocellular Carcinoma: A Patient Case Study. Biomedicines 2018, 6, 46.

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