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Biomedicines 2018, 6(2), 56; https://doi.org/10.3390/biomedicines6020056

Hypoxia, Metabolism and Immune Cell Function

1
Institut National de la Santé et de la Recherche Médicale (INSERM), Paris Cardiovascular Research Center, Unit 970, 56 Rue Leblanc, 75015 Paris, France
2
Institute of Anatomy, University of Zurich, Winterthurerstrasse 190, CH-8057 Zurich, Switzerland
*
Authors to whom correspondence should be addressed.
Received: 23 April 2018 / Revised: 8 May 2018 / Accepted: 10 May 2018 / Published: 15 May 2018
(This article belongs to the Special Issue Hypoxia)
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Abstract

Hypoxia is a hallmark of inflamed, infected or damaged tissue, and the adaptation to inadequate tissue oxygenation is regulated by hypoxia-inducible factors (HIFs). HIFs are key mediators of the cellular response to hypoxia, but they are also associated with pathological stress such as inflammation, bacteriological infection or cancer. In addition, HIFs are central regulators of many innate and adaptive immunological functions, including migration, antigen presentation, production of cytokines and antimicrobial peptides, phagocytosis as well as cellular metabolic reprogramming. A characteristic feature of immune cells is their ability to infiltrate and operate in tissues with low level of nutrients and oxygen. The objective of this article is to discuss the role of HIFs in the function of innate and adaptive immune cells in hypoxia, with a focus on how hypoxia modulates immunometabolism. View Full-Text
Keywords: oxygen; hypoxia; HIF signaling pathway; oxygen metabolism; immune cells; innate immune responses; adoptive immune responses; immunity; inflammation oxygen; hypoxia; HIF signaling pathway; oxygen metabolism; immune cells; innate immune responses; adoptive immune responses; immunity; inflammation
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Krzywinska, E.; Stockmann, C. Hypoxia, Metabolism and Immune Cell Function. Biomedicines 2018, 6, 56.

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