Ion Channel Genes in Painful Neuropathies
, Kaalindi Misra 3,†, Silvia Santoro 3, Monique M. Gerrits 4 and Janneke G. J. Hoeijmakers 2,*,‡
on behalf of the PainNet Study GroupRound 1
Reviewer 1 Report
This article is an impressive multi-author comprehensive state of the art review of the role of ion channel proteins for peripheral neuropathies.
The identification of mutations in these proteins is a long awaited breakthrough in the field of clinical neurology.
The article describes much in detail the different ion channels which maybe important for the development of peripheral neuropathies when mutated. Many experiments mentioned are knock-out studies in animals; descriptions of the relevance of these mutations in patients are increasing steadily.
The interested reviewer is eagerly waiting for a diagnostic algorithm which would serve as a guidance in identifying relevant genetic alterations (such as NGS-panels, whole exome sequencing etc.).
This will become increasingly important since personalized therapies depending upon the nature of the mutation are on the horizon.
Reviewer 2 Report
This review article was designed to describe the role of ion channels in painful neuropathies. The review lists the different ion channels that are involved in various painful peripheral neuropathies. The manuscript is well written, with proper use of grammar. I found the content of the review very well researched and organized. The two tables included in the manuscript are well connected to the text. I believe the manuscript is suitable for publication.
