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Chemosensors 2018, 6(4), 65; https://doi.org/10.3390/chemosensors6040065

Raman Spectroscopy as an Assay to Disentangle Zinc Oxide Carbon Nanotube Composites for Optimized Uric Acid Detection

Chemistry Department, Middle Tennessee State University, Murfreesboro, TN 37130, USA
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Received: 26 October 2018 / Revised: 3 December 2018 / Accepted: 6 December 2018 / Published: 12 December 2018
(This article belongs to the Special Issue Carbon Nanotube Sensors)
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Abstract

Refluxed zinc oxide (ZnO) nanoparticles (NPs) were prepared and attached to carboxylic acid functionalized multi-walled carbon nanotubes (COOH-MWNTs) via sonication. Practical optimization of electrocatalysts using sonication to disentangle a carbon nanotube composite for monitoring uric acid (UA) is shown. Monitoring UA is important for the management of medical disorders. Selection of sonication time is a crucial step in producing the desired composite. We report, for the first time, the practical use of Raman spectroscopy to tune the sonication involved in tethering ZnO NPs to the multi-walled carbon nanotube (MWNT) surface. Maximum current for detecting UA, using chronoamperometry and cyclic voltammetry, correlated with the highest sp2-hybridized carbon signal, as seen in the integrated Raman G band peak areas denoting maximum COOH-MWNT disentanglement. An array of ZnO/COOH-MWNT composites were prepared ranging from 60 to 240 min sonication times. Optimum sonication (150 min) corresponded with both maximum measured current and MWNT disentanglement. The sensor was able to quantitatively and selectively measure UA at clinically relevant concentrations (100–900 μM) with rapid current response time (< 5 s). View Full-Text
Keywords: Raman spectroscopy; electrochemical sensing; zinc oxide nanoparticles; multi-walled carbon nanotubes; chronoamperometry; cyclic voltammetry Raman spectroscopy; electrochemical sensing; zinc oxide nanoparticles; multi-walled carbon nanotubes; chronoamperometry; cyclic voltammetry
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Das, S.C.; Pandey, R.R.; Devkota, T.; Chusuei, C.C. Raman Spectroscopy as an Assay to Disentangle Zinc Oxide Carbon Nanotube Composites for Optimized Uric Acid Detection. Chemosensors 2018, 6, 65.

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