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Chemosensors 2018, 6(4), 46; https://doi.org/10.3390/chemosensors6040046

Advancements and Potential Applications of Microfluidic Approaches—A Review

1
School of Medical Science, Understanding Chronic Conditions Program, Menzies Health Institute Queensland, Griffith University (Gold Coast campus), Parklands Drive, Southport, QLD 4222, Australia
2
Department of Pharmacy, College of Medicine and Health Sciences, Ambo University, Ambo 19, Ethiopia
3
Tecnologico de Monterrey, School of Engineering and Sciences, Campus Monterrey, Ave. Eugenio Garza Sada 2501, Monterrey, N.L. CP 64849, Mexico
*
Author to whom correspondence should be addressed.
Received: 15 August 2018 / Revised: 11 October 2018 / Accepted: 12 October 2018 / Published: 15 October 2018
(This article belongs to the Special Issue Label-Free Biosensors and Chemical Sensors)
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Abstract

A micro-level technique so-called “microfluidic technology or simply microfluidic” has gained a special place as a powerful tool in bioengineering and biomedical engineering research due to its core advantages in modern science and engineering. Microfluidic technology has played a substantial role in numerous applications with special reference to bioscience, biomedical and biotechnological research. It has facilitated noteworthy development in various sectors of bio-research and upsurges the efficacy of research at the molecular level, in recent years. Microfluidic technology can manipulate sample volumes with precise control outside cellular microenvironment, at micro-level. Thus, enable the reduction of discrepancies between in vivo and in vitro environments and reduce the overall reaction time and cost. In this review, we discuss various integrations of microfluidic technologies into biotechnology and its paradigmatic significance in bio-research, supporting mechanical and chemical in vitro cellular microenvironment. Furthermore, specific innovations related to the application of microfluidics to advance microbial life, solitary and co-cultures along with a multiple-type cell culturing, cellular communications, cellular interactions, and population dynamics are also discussed. View Full-Text
Keywords: microchannel; micro-array; microstructure; biofilms; polydimethylsiloxane (PDMS); Reynolds number; Micro Electro Mechanical Systems (MEMS) microchannel; micro-array; microstructure; biofilms; polydimethylsiloxane (PDMS); Reynolds number; Micro Electro Mechanical Systems (MEMS)
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Ahmed, I.; Akram, Z.; Bule, M.H.; Iqbal, H.M.N. Advancements and Potential Applications of Microfluidic Approaches—A Review. Chemosensors 2018, 6, 46.

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