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Chemosensors 2018, 6(2), 23;

Label-Free Sensing in Microdroplet-Based Microfluidic Systems

Institute of Materials Science and Nanotechnology, National Nanotechnology Research Center (UNAM), Bilkent University, Ankara 06800, Turkey
Author to whom correspondence should be addressed.
Received: 31 March 2018 / Revised: 14 May 2018 / Accepted: 17 May 2018 / Published: 24 May 2018
(This article belongs to the Special Issue Label-Free Biosensors and Chemical Sensors)
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Droplet microfluidic systems have evolved as fluidic platforms that use much less sample volume and provide high throughput for biochemical analysis compared to conventional microfluidic devices. The variety of droplet fluidic applications triggered several detection techniques to be applied for analysis of droplets. In this review, we focus on label-free droplet detection techniques that were adapted to various droplet microfluidic platforms. We provide a classification of most commonly used droplet platform technologies. Then we discuss the examples of various label-free droplet detection schemes implemented for these platforms. While providing the research landscape for label-free droplet detection methods, we aim to highlight the strengths and shortcomings of each droplet platform so that a more targeted approach can be taken by researchers when selecting a droplet platform and a detection scheme for any given application. View Full-Text
Keywords: microdroplets; microfluidics; two-phase flow; digital microfluidics; label-free sensing microdroplets; microfluidics; two-phase flow; digital microfluidics; label-free sensing

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Kalantarifard, A.; Saateh, A.; Elbuken, C. Label-Free Sensing in Microdroplet-Based Microfluidic Systems. Chemosensors 2018, 6, 23.

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