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Article

Awareness of Malocclusion Is Closely Associated with Allergic Rhinitis, Asthma, and Arrhythmia in Late Adolescents

1
Division for Health Service Promotion, The University of Tokyo, Tokyo 113-0033, Japan
2
Department of Oral & Maxillofacial Surgery, The University of Tokyo Hospital, Tokyo 113-8655, Japan
3
Division of Epigenomics, National Cancer Center Research Institute, Tokyo 104-0045, Japan
*
Author to whom correspondence should be addressed.
Healthcare 2020, 8(3), 209; https://doi.org/10.3390/healthcare8030209
Received: 10 June 2020 / Revised: 7 July 2020 / Accepted: 9 July 2020 / Published: 12 July 2020
(This article belongs to the Section Health Assessments)
Background: Oral infectious diseases are typified by dental caries and periodontal diseases and are known to be associated with various systemic diseases. However, clear associations between occlusal disorders and systemic diseases have not yet been established. We investigated the association between an awareness of malocclusion and common diseases in late adolescence. Methods: We retrospectively reviewed the data of mandatory medical questionnaires that are a legal requirement of the freshman medical checkup. We collected the data of all the students who completed the questionnaires between April 2017 and 2019. The data were analyzed using the χ2 test and multivariate analysis was performed with a binomial logistic regression model. Results: The subjects were 9098 students aged 17–19 (mean age 18.3 years). The rate of awareness of malocclusion was 2.14% (195 out of 9098 eligible subjects; 160 males and 35 females). These students had significantly greater rates of allergic rhinitis, asthma, and arrhythmia (p < 0.001). Multivariate analysis revealed significant rates of allergic rhinitis (odds ratio [OR] 2.184, 95% confidence interval [CI]: 1.468–3.250, p < 0.001), asthma (OR 1.843, 95%CI: 1.153–2.945, p = 0.011), and arrhythmia (OR 2.809, 95%CI: 1.083–7.288, p = 0.034) among students with an awareness of malocclusion. Conclusion: We identified close associations between an awareness of malocclusion and systemic diseases including allergic rhinitis, asthma, and arrhythmia in the late adolescent population. These results reinforce the associations between malocclusion and allergic rhinitis and asthma, as well as providing novel insight into the association of malocclusion and arrhythmia. However, further research is necessary to confirm the associations and explore the mechanisms underlying these associations. View Full-Text
Keywords: awareness of malocclusion; malocclusion; occlusal disorder; adolescence; systemic disease; asthma; allergic rhinitis; arrhythmia; heart disease awareness of malocclusion; malocclusion; occlusal disorder; adolescence; systemic disease; asthma; allergic rhinitis; arrhythmia; heart disease
MDPI and ACS Style

Abe, M.; Mitani, A.; Yao, A.; Zong, L.; Hoshi, K.; Yanagimoto, S. Awareness of Malocclusion Is Closely Associated with Allergic Rhinitis, Asthma, and Arrhythmia in Late Adolescents. Healthcare 2020, 8, 209. https://doi.org/10.3390/healthcare8030209

AMA Style

Abe M, Mitani A, Yao A, Zong L, Hoshi K, Yanagimoto S. Awareness of Malocclusion Is Closely Associated with Allergic Rhinitis, Asthma, and Arrhythmia in Late Adolescents. Healthcare. 2020; 8(3):209. https://doi.org/10.3390/healthcare8030209

Chicago/Turabian Style

Abe, Masanobu, Akihisa Mitani, Atsushi Yao, Liang Zong, Kazuto Hoshi, and Shintaro Yanagimoto. 2020. "Awareness of Malocclusion Is Closely Associated with Allergic Rhinitis, Asthma, and Arrhythmia in Late Adolescents" Healthcare 8, no. 3: 209. https://doi.org/10.3390/healthcare8030209

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