The basic characteristic of batch bioreactors is their inability to inflow or outflow the substances during the fermentation process. This follows in the simple construction and maintenance, which is the significant advantage of batch bioreactors. Unfortunately, this characteristic also results in the inability of the current industrial and laboratory batch bioreactors to control fermentation production during the process duration. In some recent studies, it was shown that changing the temperature could influence the execution of the fermentation process. The presented paper shows that this phenomenon could be used to develop the closed-loop control system for the fermentation production control in batch bioreactors. First, based on theoretical work, experiments, and numerical methods, the appropriate structure of the mathematical model was determined and parameters were identified. Next, the closed-loop control system structure for batch bioreactor was proposed, and the linear and adaptive control system based on this structure and the derived and identified model were developed. Both modeling and adaptive control system design are new and represent original contributions. As expected, due to the non-linearity of the controlled plant, the adaptive control represents a more successful approach. The simulation and experimental results were used to confirm the applicability of the proposed solution.
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