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Open AccessArticle

Analysis of Reference Ranges of Total Serum Protein in Namibia: Clinical Implications

1
Department of Health Sciences, Faculty of Health and Applied Sciences, Namibia University of Science and Technology (NUST), Private Bag 13388, Windhoek, Namibia
2
Bioresource Engineering Research Group (BioERG), Department of Biotechnology, Faculty of Applied Sciences, Cape Peninsula University of Technology, P.O. Box 652, Cape Town 8000, South Africa
3
School of Chemical and Minerals Engineering, North-West University, Private Bag X1290, Potchefstroom 2520, South Africa
*
Author to whom correspondence should be addressed.
Proteomes 2020, 8(2), 7; https://doi.org/10.3390/proteomes8020007
Received: 14 February 2020 / Revised: 22 March 2020 / Accepted: 30 March 2020 / Published: 15 April 2020
(This article belongs to the Special Issue Human Proteomics)
A reference range is an essential part of clinical laboratory test interpretation and patient care. The levels of total serum protein (TSP) are measured in sera to assess nutritional, liver, and kidney disorders. This study determined the TSP reference range with respect to gender, age, and region in Namibia. A retrospective cross-sectional study was conducted to determine the TSP reference range among 78,477 healthy participants within the ages of less than one year to more than 65 yrs in 14 regions of Namibia. The reference range of TSP was 51–91 g/L for females and 51–92 g/L for males. A reduced TSP range of 48.00–85.55 g/L (2.5–97.5 percentiles) was established at <1–5 years and increased towards adolescence. An uttermost range of 54–93 g/L was observed from 36–65 years of age. At the age >65 years; a steady decline in the reference range (51.00–89 g/L) was recorded. An upper TSP range of 53–92 g/L (2.5–97.5 percentiles) was detected in Erongo, Zambezi, Hardap, Kavango East, and a comparable trend was also seen in Omusati with a 54–91 g/L range. Meanwhile; a reduced TSP range of 50–89 g/L was identified in Ohangwena. This study showed that gender, age, and geographical location can impact TSP levels with a significant clinical difference (p < 0.05) between each category. View Full-Text
Keywords: clinical laboratory; non-parametric; reference range; total serum protein clinical laboratory; non-parametric; reference range; total serum protein
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MDPI and ACS Style

Henok, J.N.; Okeleye, B.I.; Omodanisi, E.I.; Ntwampe, S.K.O.; Aboua, Y.G. Analysis of Reference Ranges of Total Serum Protein in Namibia: Clinical Implications. Proteomes 2020, 8, 7. https://doi.org/10.3390/proteomes8020007

AMA Style

Henok JN, Okeleye BI, Omodanisi EI, Ntwampe SKO, Aboua YG. Analysis of Reference Ranges of Total Serum Protein in Namibia: Clinical Implications. Proteomes. 2020; 8(2):7. https://doi.org/10.3390/proteomes8020007

Chicago/Turabian Style

Henok, Josephine N.; Okeleye, Benjamin I.; Omodanisi, Elizabeth I.; Ntwampe, Seteno K.O.; Aboua, Yapo G. 2020. "Analysis of Reference Ranges of Total Serum Protein in Namibia: Clinical Implications" Proteomes 8, no. 2: 7. https://doi.org/10.3390/proteomes8020007

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