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Open AccessReview

Melanoma-Derived Extracellular Vesicles: Focus on Their Proteome

Department of Glycoconjugate Biochemistry, Institute of Zoology and Biomedical Research, Jagiellonian University, Gronostajowa 9, 30-387 Krakow, Poland
Department of Medical Physics, M. Smoluchowski Institute of Physics, Jagiellonian University, Łojasiewicza 11, 30-348 Krakow, Poland
Author to whom correspondence should be addressed.
Proteomes 2019, 7(2), 21;
Received: 27 March 2019 / Revised: 30 April 2019 / Accepted: 6 May 2019 / Published: 13 May 2019
(This article belongs to the Special Issue Proteomes of Extracellular Vesicles)
PDF [744 KB, uploaded 13 May 2019]


Malignant melanoma is one of the most aggressive types of cancer, and its incidence is increasing rapidly each year. Despite the extensive research into improved diagnostic and treatment methods, early detection and disease constraint still present significant challenges. As successful isolation protocols have been developed, extracellular vesicles (EVs) have become the subject of extensive investigation in terms of their role in cancer progression and as a possible source of disease biomarkers. Besides functional studies, quantitative and qualitative proteomics have recently emerged as promising tools for the advancement of melanoma biomarkers. Nevertheless, the amount of data concerning the proteome of melanoma-derived EVs is still very limited. In this review we cover the current knowledge on protein content of melanoma-derived EVs, with a focus on their potential role in the development and progression of melanomas. View Full-Text
Keywords: proteomics; extracellular vesicles; melanoma; ectosomes; exosomes; cancer proteomics; extracellular vesicles; melanoma; ectosomes; exosomes; cancer

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Surman, M.; Stępień, E.; Przybyło, M. Melanoma-Derived Extracellular Vesicles: Focus on Their Proteome. Proteomes 2019, 7, 21.

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