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Open AccessFeature PaperReview

Proteogenomics in Aid of Host–Pathogen Interaction Studies: A Bacterial Perspective

by Ursula Fels 1,2, Kris Gevaert 1,2 and Petra Van Damme 1,2,*
VIB-UGent Center for Medical Biotechnology, Albert Baertsoenkaai 3, B-9000 Ghent, Belgium
Department of Biochemistry, Ghent University, B-9000 Ghent, Belgium
Author to whom correspondence should be addressed.
Proteomes 2017, 5(4), 26;
Received: 25 August 2017 / Revised: 2 October 2017 / Accepted: 8 October 2017 / Published: 11 October 2017
(This article belongs to the Special Issue Proteomic Analysis of Host-Microbial Pathogen Interactions)
By providing useful tools to study host–pathogen interactions, next-generation omics has recently enabled the study of gene expression changes in both pathogen and infected host simultaneously. However, since great discriminative power is required to study pathogen and host simultaneously throughout the infection process, the depth of quantitative gene expression profiling has proven to be unsatisfactory when focusing on bacterial pathogens, thus preferentially requiring specific strategies or the development of novel methodologies based on complementary omics approaches. In this review, we focus on the difficulties encountered when making use of proteogenomics approaches to study bacterial pathogenesis. In addition, we review different omics strategies (i.e., transcriptomics, proteomics and secretomics) and their applications for studying interactions of pathogens with their host. View Full-Text
Keywords: host–pathogen interaction; bacterial pathogens; infection biology; proteogenomics host–pathogen interaction; bacterial pathogens; infection biology; proteogenomics
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Fels, U.; Gevaert, K.; Van Damme, P. Proteogenomics in Aid of Host–Pathogen Interaction Studies: A Bacterial Perspective. Proteomes 2017, 5, 26.

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