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Open AccessCommunication

The Effects of Triterpenoid Saponins from the Seeds of Momordica cochinchinensis on Adipocyte Differentiation and Mature Adipocyte Inflammation

1
School of Pharmacy, Sungkyunkwan University, Suwon 16419, Korea
2
College of Pharmacy, Chonnam National University, Gwangju 61186, Korea
3
Institute of Pharmaceutical Sciences, College of Pharmacy, CHA University, Seongnam 13488, Korea
4
School of Chemical Engineering, Sungkyunkwan University, Suwon 16419, Korea
*
Authors to whom correspondence should be addressed.
Plants 2020, 9(8), 984; https://doi.org/10.3390/plants9080984
Received: 7 July 2020 / Revised: 27 July 2020 / Accepted: 31 July 2020 / Published: 3 August 2020
Obesity is a medical condition in which abnormal or excessive fat accumulates to an extent that is associated with various diseases. In our ongoing research to figure out natural products with anti-obesity effects, a phytochemical investigation of the EtOH extract of the seeds of Momordica cochinchinensis was carried out, which resulted in the isolation of two major triterpenoid saponins: gypsogenin 3-O-β-d-galactopyranosyl(1→2)-[α-l-rhamnopyranosyl (1→3)]-β-d-glucuronopyranoside (1) and quillaic acid 3-O-β-d-galactopyranosyl(1→2)-[α-l-rhamnopyranosyl(1→3)]-β-d-glucuronopyranoside (2). Then, the effects of the isolated triterpenoid saponins (1 and 2) on adipocyte differentiation were evaluated, and it was demonstrated that the isolated saponin (1) showed inhibitory effects on adipogenesis. In mature adipocytes, the isolated saponin (1) reversed tumor necrosis factor α (TNFα)-induced proinflammatory cytokine gene expression. Additionally, the isolated saponin (1) reduced lipolytic gene expression leading to decreased basal lipolysis activity. Collectively, these findings suggest that saponin (1) of M. cochinchinensis exerts beneficial effects in the regulation of adipogenesis and adipocyte inflammation and could be a potential therapeutic alternative in the treatment of obesity-induced metabolic diseases. View Full-Text
Keywords: Saponin; Momordica cochinchinensis; obesity; diabetes; adipocyte Saponin; Momordica cochinchinensis; obesity; diabetes; adipocyte
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MDPI and ACS Style

Yu, J.S.; Sahar, N.E.; Bi, Y.-R.; Jung, K.; Pang, C.; Huh, J.Y.; Kim, K.H. The Effects of Triterpenoid Saponins from the Seeds of Momordica cochinchinensis on Adipocyte Differentiation and Mature Adipocyte Inflammation. Plants 2020, 9, 984. https://doi.org/10.3390/plants9080984

AMA Style

Yu JS, Sahar NE, Bi Y-R, Jung K, Pang C, Huh JY, Kim KH. The Effects of Triterpenoid Saponins from the Seeds of Momordica cochinchinensis on Adipocyte Differentiation and Mature Adipocyte Inflammation. Plants. 2020; 9(8):984. https://doi.org/10.3390/plants9080984

Chicago/Turabian Style

Yu, Jae S.; Sahar, Namood E.; Bi, Yan-Ran; Jung, Kiwon; Pang, Changhyun; Huh, Joo Y.; Kim, Ki H. 2020. "The Effects of Triterpenoid Saponins from the Seeds of Momordica cochinchinensis on Adipocyte Differentiation and Mature Adipocyte Inflammation" Plants 9, no. 8: 984. https://doi.org/10.3390/plants9080984

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