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Article

Application of Deep Eutectic Solvents for the Extraction of Rutin and Rosmarinic Acid from Satureja montana L. and Evaluation of the Extracts Antiradical Activity

1
Faculty of Food Technology Osijek, Josip Juraj Strossmayer University of Osijek, Franje Kuhača 20, 31000 Osijek, Croatia
2
Faculty of Technology, University of Novi Sad, Bulevar cara Lazara 1, 21000 Novi Sad, Serbia
3
Faculty of Chemistry and Technology, University of Split, Ruđera Boškovića 35, 21000 Split, Croatia
*
Author to whom correspondence should be addressed.
Plants 2020, 9(2), 153; https://doi.org/10.3390/plants9020153
Received: 22 December 2019 / Revised: 15 January 2020 / Accepted: 23 January 2020 / Published: 26 January 2020
(This article belongs to the Special Issue 2019 Feature Papers by Plants’ Editorial Board Members)
Satureja montana L. was used in the current research as the plant exhibits numerous health-promoting benefits due to its specific chemical composition. The extraction method based on deep eutectic solvents (DESs) was used for the extraction of rutin and rosmarinic acid from this plant. Five different choline chloride-based DESs with different volumes of water (10%, 30%, and 50% (v/v)) were used for the extraction at different temperatures (30, 50, and 70 °C) to investigate the influence on rosmarinic acid and rutin content obtained by high-performance liquid chromatography with diode-array detector (HPLC-DAD) in the obtained extracts. A principal component analysis was employed to explore and visualize the influence of applied parameters on the efficiency of the extraction procedure of rutin and rosmarinic acid. Among the tested DESs, choline chloride:lactic acid (mole ratio 1:2) and choline chloride:levulinic acid (mole ratio 1:2) were the most suitable for the extraction of rutin, while for rosmarinic acid choline chloride:urea (mole ratio 1:2) was the most effective solvent. The extract showing the best antiradical activity was obtained with choline chloride:urea (mole ratio 1:1) at 30 °C and 50% H2O (v/v). View Full-Text
Keywords: deep eutectic solvents; extraction; rutin; rosmarinic acid; Satureja montana L.; principal component analysis deep eutectic solvents; extraction; rutin; rosmarinic acid; Satureja montana L.; principal component analysis
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MDPI and ACS Style

Jakovljević, M.; Vladić, J.; Vidović, S.; Pastor, K.; Jokić, S.; Molnar, M.; Jerković, I. Application of Deep Eutectic Solvents for the Extraction of Rutin and Rosmarinic Acid from Satureja montana L. and Evaluation of the Extracts Antiradical Activity. Plants 2020, 9, 153. https://doi.org/10.3390/plants9020153

AMA Style

Jakovljević M, Vladić J, Vidović S, Pastor K, Jokić S, Molnar M, Jerković I. Application of Deep Eutectic Solvents for the Extraction of Rutin and Rosmarinic Acid from Satureja montana L. and Evaluation of the Extracts Antiradical Activity. Plants. 2020; 9(2):153. https://doi.org/10.3390/plants9020153

Chicago/Turabian Style

Jakovljević, Martina, Jelena Vladić, Senka Vidović, Kristian Pastor, Stela Jokić, Maja Molnar, and Igor Jerković. 2020. "Application of Deep Eutectic Solvents for the Extraction of Rutin and Rosmarinic Acid from Satureja montana L. and Evaluation of the Extracts Antiradical Activity" Plants 9, no. 2: 153. https://doi.org/10.3390/plants9020153

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