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Open AccessReview

Polyamines as Quality Control Metabolites Operating at the Post-Transcriptional Level

1
Instituto de Biología Molecular y Celular de Plantas, Consejo Superior de Investigaciones Científicas-Universitat Politècnica de València, 46022 Valencia, Spain
2
Biotechnology Application and Research Center, and Department of Molecular Biology, Faculty of Science and Letter, Bilecik Seyh Edebali University, 11230 Bilecik, Turkey
*
Author to whom correspondence should be addressed.
Plants 2019, 8(4), 109; https://doi.org/10.3390/plants8040109
Received: 2 April 2019 / Revised: 17 April 2019 / Accepted: 19 April 2019 / Published: 24 April 2019
(This article belongs to the Special Issue Plant Polyamines)
Plant polyamines (PAs) have been assigned a large number of physiological functions with unknown molecular mechanisms in many cases. Among the most abundant and studied polyamines, two of them, namely spermidine (Spd) and thermospermine (Tspm), share some molecular functions related to quality control pathways for tightly regulated mRNAs at the level of translation. In this review, we focus on the roles of Tspm and Spd to facilitate the translation of mRNAs containing upstream ORFs (uORFs), premature stop codons, and ribosome stalling sequences that may block translation, thus preventing their degradation by quality control mechanisms such as the nonsense-mediated decay pathway and possible interactions with other mRNA quality surveillance pathways. View Full-Text
Keywords: polyamines; spermidine; thermospermine; nonsense-mediated decay; no-go decay; non-stop decay; quality control; translation polyamines; spermidine; thermospermine; nonsense-mediated decay; no-go decay; non-stop decay; quality control; translation
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MDPI and ACS Style

Poidevin, L.; Unal, D.; Belda-Palazón, B.; Ferrando, A. Polyamines as Quality Control Metabolites Operating at the Post-Transcriptional Level. Plants 2019, 8, 109.

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