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Article

Chemical Profiling and Biological Evaluation of Nepeta baytopii Extracts and Essential Oil: An Endemic Plant from Turkey

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Physiology and Biochemistry Research Laboratory, Department of Biology, Science Faculty, Selcuk University, Campus, Konya 42130, Turkey
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Department of Health Sciences, Faculty of Medicine and Health Sciences, University of Mauritius, Réduit 80837, Mauritius
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Agricultural and Molecular Research and Service Institute, University of Nyíregyháza, 4405 Nyíregyháza, Hungary
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Centre of Marine Sciences, Faculty of Sciences and Technology, University of Algarve, Ed. 7, Campus of Gambelas, 8005-139 Faro, Portugal
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Department of Landscape Architecture, Faculty of Agriculture, Bingol University, Bingöl 12000, Turkey
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Department of Botany, Pertek Sakine Genç Vocational School, Munzur University, Tunceli 62000, Turkey
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Department of Chemistry, Faculty of Sciences and Arts, Bingol University, Bingöl 12000, Turkey
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Department of Molecular Medicine and Medical Biotechnology, University of Naples Federico II, via Pansini, 5, 80131 Naples, Italy
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Department of Pharmacy, University of Naples Federico II, via D. Montesano 49, 80131 Naples, Italy
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Authors to whom correspondence should be addressed.
Academic Editor: Petko Denev
Plants 2021, 10(6), 1176; https://doi.org/10.3390/plants10061176
Received: 22 May 2021 / Revised: 4 June 2021 / Accepted: 7 June 2021 / Published: 9 June 2021
(This article belongs to the Special Issue Polyphenols in Plants)
Nepeta baytopii is a poorly studied, endemic Nepeta species (Lamiaceae) of Turkey. For the first time, the biological activities (antioxidant, enzyme inhibition, and cytotoxicity properties) of the hexane, ethyl acetate, methanol, water/methanol, and water extracts and essential oil prepared from N. baytopii aerial parts were assessed. Hydro-methanol (41.25 mg gallic acid equivalent (GAE)/g) and water extracts (50.30 mg GAE/g), respectively showed the highest radical scavenging (94.40 and 129.22 mg Trolox equivalent (TE)/g, for 2,2-diphenyl-1-picrylhydrazyl radical and 2,2-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid radical scavenging assays) and reducing (229.37 and 129.55 mg TE/g, for ferric-reducing antioxidant power and cupric-reducing antioxidant capacity assays) capacities in vitro. An interestingly high inhibition was observed for ethyl acetate extract against butyrylcholinesterase (10.85 mg galantamine equivalent/g). The methanol extract showed high cytotoxicity (31.7%) against HepG2 cells. Caryophyllene oxide was identified in high concentrations in the essential oil (39.3%). Luteolin and apigenin and their derivatives were identified from the methanol and water extracts. The results obtained from this study highlighted that the abundance of highly bioactive compounds from Nepeta baytopii ensures the multiple biological activities of the tested extracts, and this suggests a potential use in the pharmaceutical and nutraceutical fields, and therefore should be investigated further. View Full-Text
Keywords: Nepeta; polyphenols; antioxidant; enzyme inhibition; phytopharmaceutics Nepeta; polyphenols; antioxidant; enzyme inhibition; phytopharmaceutics
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MDPI and ACS Style

Zengin, G.; Mahomoodally, M.F.; Aktumsek, A.; Jekő, J.; Cziáky, Z.; Rodrigues, M.J.; Custodio, L.; Polat, R.; Cakilcioglu, U.; Ayna, A.; Gallo, M.; Montesano, D.; Picot-Allain, C. Chemical Profiling and Biological Evaluation of Nepeta baytopii Extracts and Essential Oil: An Endemic Plant from Turkey. Plants 2021, 10, 1176. https://doi.org/10.3390/plants10061176

AMA Style

Zengin G, Mahomoodally MF, Aktumsek A, Jekő J, Cziáky Z, Rodrigues MJ, Custodio L, Polat R, Cakilcioglu U, Ayna A, Gallo M, Montesano D, Picot-Allain C. Chemical Profiling and Biological Evaluation of Nepeta baytopii Extracts and Essential Oil: An Endemic Plant from Turkey. Plants. 2021; 10(6):1176. https://doi.org/10.3390/plants10061176

Chicago/Turabian Style

Zengin, Gokhan, Mohamad F. Mahomoodally, Abdurrahman Aktumsek, József Jekő, Zoltán Cziáky, Maria J. Rodrigues, Luisa Custodio, Rıdvan Polat, Ugur Cakilcioglu, Adnan Ayna, Monica Gallo, Domenico Montesano, and Carene Picot-Allain. 2021. "Chemical Profiling and Biological Evaluation of Nepeta baytopii Extracts and Essential Oil: An Endemic Plant from Turkey" Plants 10, no. 6: 1176. https://doi.org/10.3390/plants10061176

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