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Chemical Constituents of the Leaves of Diospyros kaki (Persimmon)

KIST Gangneung Institute of Natural Products, Korea Institute of Science and Technology (KIST), Gangneung 25451, Korea
Department of Life and Nanopharmaceutical Sciences, Graduate School, Kyung Hee University, Seoul 02447, Korea
Authors to whom correspondence should be addressed.
These authors contributed equally to this work and joint first authors.
Academic Editors: Alessandra Braca and Marinella De Leo
Plants 2021, 10(10), 2032;
Received: 7 September 2021 / Revised: 22 September 2021 / Accepted: 26 September 2021 / Published: 28 September 2021
(This article belongs to the Special Issue Chemical Profiling and Biological Activity of Plant Natural Compounds)
Diospyros kaki (persimmon) leaves have long been utilized as traditional medicine for the treatment of ischemic stroke, angina, and hypertension and as a healthy beverage and cosmetic for anti-aging. This study aimed to isolate as many compounds as possible from an ethanol extract of the persimmon leaves to identify the biologically active compounds. The antioxidative effect of the ethyl acetate layer from the ethanol extract of the persimmon leaves was demonstrated by 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay and online high-performance liquid chromatography-2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (HPLC-ABTS) analysis. A new flavonoid, kaempferol-3-O-β-d-2″-coumaroylgalactoside (1), and a new natural compound, kaempferol-3-O-β-d-2″-feruloylglucoside (3) were isolated from the ethyl acetate layer, along with 25 previously known compounds, including fourteen flavonoids, one ionone, two coumarins, seven triterpenoids, and one acetophenone. Their structures were determined by the interpretation of spectrometric and spectroscopic data. All isolated compounds were rapidly evaluated using an online HPLC-ABTS assay, and of these, compounds 48, 11, 13, 15, and 16 clearly showed antioxidative effects. The amount of these compounds was 0.3–0.65% of the extract. View Full-Text
Keywords: Diospyros kaki; persimmon leaves; flavonoid; antioxidant Diospyros kaki; persimmon leaves; flavonoid; antioxidant
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MDPI and ACS Style

Kwon, J.; Park, J.-E.; Lee, J.-S.; Lee, J.-H.; Hwang, H.; Jung, S.-H.; Kwon, H.-C.; Jang, D.-S. Chemical Constituents of the Leaves of Diospyros kaki (Persimmon). Plants 2021, 10, 2032.

AMA Style

Kwon J, Park J-E, Lee J-S, Lee J-H, Hwang H, Jung S-H, Kwon H-C, Jang D-S. Chemical Constituents of the Leaves of Diospyros kaki (Persimmon). Plants. 2021; 10(10):2032.

Chicago/Turabian Style

Kwon, Jaeyoung, Jeong-Eun Park, Jin-Su Lee, Jung-Hwan Lee, Hoseong Hwang, Sang-Hoon Jung, Hak-Cheol Kwon, and Dae-Sik Jang. 2021. "Chemical Constituents of the Leaves of Diospyros kaki (Persimmon)" Plants 10, no. 10: 2032.

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