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Review

Regulating Retinoic Acid Availability during Development and Regeneration: The Role of the CYP26 Enzymes

1
Developmental Biology of Birth Defects, UCL-GOS Institute of Child Health, 30 Guilford St, London WC1N 1EH, UK
2
Institute of Medical and Biomedical Education St George’s, University of London, Cranmer Terrace, Tooting, London SW17 0RE, UK
J. Dev. Biol. 2020, 8(1), 6; https://doi.org/10.3390/jdb8010006
Received: 27 September 2019 / Revised: 17 February 2020 / Accepted: 17 February 2020 / Published: 5 March 2020
(This article belongs to the Special Issue Retinoids in Development 2019)
This review focuses on the role of the Cytochrome p450 subfamily 26 (CYP26) retinoic acid (RA) degrading enzymes during development and regeneration. Cyp26 enzymes, along with retinoic acid synthesising enzymes, are absolutely required for RA homeostasis in these processes by regulating availability of RA for receptor binding and signalling. Cyp26 enzymes are necessary to generate RA gradients and to protect specific tissues from RA signalling. Disruption of RA homeostasis leads to a wide variety of embryonic defects affecting many tissues. Here, the function of CYP26 enzymes is discussed in the context of the RA signalling pathway, enzymatic structure and biochemistry, human genetic disease, and function in development and regeneration as elucidated from animal model studies. View Full-Text
Keywords: CYP26; retinoic acid; embryonic development CYP26; retinoic acid; embryonic development
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MDPI and ACS Style

Roberts, C. Regulating Retinoic Acid Availability during Development and Regeneration: The Role of the CYP26 Enzymes. J. Dev. Biol. 2020, 8, 6. https://doi.org/10.3390/jdb8010006

AMA Style

Roberts C. Regulating Retinoic Acid Availability during Development and Regeneration: The Role of the CYP26 Enzymes. Journal of Developmental Biology. 2020; 8(1):6. https://doi.org/10.3390/jdb8010006

Chicago/Turabian Style

Roberts, Catherine. 2020. "Regulating Retinoic Acid Availability during Development and Regeneration: The Role of the CYP26 Enzymes" J. Dev. Biol. 8, no. 1: 6. https://doi.org/10.3390/jdb8010006

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