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The Molecular Mechanism of Epithelial–Mesenchymal Transition for Breast Carcinogenesis

by Chia-Jung Li 1,2,†, Pei-Yi Chu 3,4,5,†, Giou-Teng Yiang 6,7 and Meng-Yu Wu 6,7,*
Department of Obstetrics and Gynecology, Kaohsiung Veterans General Hospital, Kaohsiung 813, Taiwan
Institute of Biomedical Sciences, National Sun Yat-Sen University, Kaohsiung 804, Taiwan
School of Medicine, College of Medicine, Fu Jen Catholic University, New Taipei 242, Taiwan
Department of Pathology, Show Chwan Memorial Hospital, Changhua 500, Taiwan
Department of Health Food, Chung Chou University of Science and Technology, Changhua 510, Taiwan
Department of Emergency Medicine, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei 231, Taiwan
Department of Emergency Medicine, School of Medicine, Tzu Chi University, Hualien 970, Taiwan
Author to whom correspondence should be addressed.
These authors contributed equally to this paper.
Biomolecules 2019, 9(9), 476;
Received: 15 July 2019 / Revised: 9 September 2019 / Accepted: 9 September 2019 / Published: 11 September 2019
(This article belongs to the Special Issue TGF-Beta Signaling in Physiology and Pathology)
The transforming growth factor-β (TGF-β) signaling pathway plays multiple regulatory roles in the tumorigenesis and development of cancer. TGF-β can inhibit the growth and proliferation of epithelial cells and induce apoptosis, thereby playing a role in inhibiting breast cancer. Therefore, the loss of response in epithelial cells that leads to the inhibition of cell proliferation due to TGF-β is a landmark event in tumorigenesis. As tumors progress, TGF-β can promote tumor cell invasion, metastasis, and drug resistance. At present, the above-mentioned role of TGF-β is related to the interaction of multiple signaling pathways in the cell, which can attenuate or abolish the inhibition of proliferation and apoptosis-promoting effects of TGF-β and enhance its promotion of tumor progression. This article focuses on the molecular mechanisms through which TGF-β interacts with multiple intracellular signaling pathways in tumor progression and the effects of these interactions on tumorigenesis. View Full-Text
Keywords: breast cancer; transforming growth factor-β; epithelial-to-mesenchymal transition; signaling pathway breast cancer; transforming growth factor-β; epithelial-to-mesenchymal transition; signaling pathway
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MDPI and ACS Style

Li, C.-J.; Chu, P.-Y.; Yiang, G.-T.; Wu, M.-Y. The Molecular Mechanism of Epithelial–Mesenchymal Transition for Breast Carcinogenesis. Biomolecules 2019, 9, 476.

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