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The Molecular Mechanism of Epithelial–Mesenchymal Transition for Breast Carcinogenesis

by Chia-Jung Li 1,2,†, Pei-Yi Chu 3,4,5,†, Giou-Teng Yiang 6,7 and Meng-Yu Wu 6,7,*
1
Department of Obstetrics and Gynecology, Kaohsiung Veterans General Hospital, Kaohsiung 813, Taiwan
2
Institute of Biomedical Sciences, National Sun Yat-Sen University, Kaohsiung 804, Taiwan
3
School of Medicine, College of Medicine, Fu Jen Catholic University, New Taipei 242, Taiwan
4
Department of Pathology, Show Chwan Memorial Hospital, Changhua 500, Taiwan
5
Department of Health Food, Chung Chou University of Science and Technology, Changhua 510, Taiwan
6
Department of Emergency Medicine, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei 231, Taiwan
7
Department of Emergency Medicine, School of Medicine, Tzu Chi University, Hualien 970, Taiwan
*
Author to whom correspondence should be addressed.
These authors contributed equally to this paper.
Biomolecules 2019, 9(9), 476; https://doi.org/10.3390/biom9090476
Received: 15 July 2019 / Revised: 9 September 2019 / Accepted: 9 September 2019 / Published: 11 September 2019
(This article belongs to the Special Issue TGF-Beta Signaling in Physiology and Pathology)
The transforming growth factor-β (TGF-β) signaling pathway plays multiple regulatory roles in the tumorigenesis and development of cancer. TGF-β can inhibit the growth and proliferation of epithelial cells and induce apoptosis, thereby playing a role in inhibiting breast cancer. Therefore, the loss of response in epithelial cells that leads to the inhibition of cell proliferation due to TGF-β is a landmark event in tumorigenesis. As tumors progress, TGF-β can promote tumor cell invasion, metastasis, and drug resistance. At present, the above-mentioned role of TGF-β is related to the interaction of multiple signaling pathways in the cell, which can attenuate or abolish the inhibition of proliferation and apoptosis-promoting effects of TGF-β and enhance its promotion of tumor progression. This article focuses on the molecular mechanisms through which TGF-β interacts with multiple intracellular signaling pathways in tumor progression and the effects of these interactions on tumorigenesis. View Full-Text
Keywords: breast cancer; transforming growth factor-β; epithelial-to-mesenchymal transition; signaling pathway breast cancer; transforming growth factor-β; epithelial-to-mesenchymal transition; signaling pathway
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MDPI and ACS Style

Li, C.-J.; Chu, P.-Y.; Yiang, G.-T.; Wu, M.-Y. The Molecular Mechanism of Epithelial–Mesenchymal Transition for Breast Carcinogenesis. Biomolecules 2019, 9, 476.

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