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Biomolecules 2019, 9(2), 69; https://doi.org/10.3390/biom9020069

Surface-Degradable Drug-Eluting Stent with Anticoagulation, Antiproliferation, and Endothelialization Functions

1
Department of Anatomy and Histology and Embryology, Medical School of Ningbo University, Ningbo 315211, China
2
Key Laboratory of Advanced Technology of Materials of Education Ministry, School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu 610031, China
3
John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA
*
Authors to whom correspondence should be addressed.
Received: 5 December 2018 / Revised: 29 January 2019 / Accepted: 6 February 2019 / Published: 18 February 2019
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Abstract

Drug-eluting stents (DES) have been widely applied for saving the life of patients with coronary artery diseases (CADs). However, conventional polymers such as polylactic acid (PLA) and poly (lactic-co-glycolic acid) (PLGA), which are widely applied for drug-eluting stents studies, have serious bulk erosion problems, like high local acidity and poor mechanical properties. Instead, we chose surface erosion polymer poly (1, 3-trimethylene carbonate) (PTMC) as a drug carrier in this study. Here, we fabricated and characterized a novel durable-polymer drug-eluting 316 L stainless steel (SS) stent, in which the inner surface was coated with a Ti–O film using the magnetron sputtering method to promote the growth of endothelial cells (ECs). On the outer layer of the stent, first, a Ti–O film was deposited and, then, on top of it a rapamycin-loaded PTMC coat was deposited using the ultrasonic atomization spray method. This dual coating inhibited the migration and expansion of smooth muscle cells (SMCs). The drug coating also inhibited the adhesion/activation of platelets. In tests on dogs, it was found the novel stent promoted re-endothelialization and reduced restenosis, in contrast to the plain SS stent. Thus, the novel stent may have promise for use in treating patients with CAD. View Full-Text
Keywords: stent coatings; surface erosion; drug carrier; rapamycin; smooth muscle cells stent coatings; surface erosion; drug carrier; rapamycin; smooth muscle cells
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Hou, R.; Wu, L.; Wang, J.; Yang, Z.; Tu, Q.; Zhang, X.; Huang, N. Surface-Degradable Drug-Eluting Stent with Anticoagulation, Antiproliferation, and Endothelialization Functions. Biomolecules 2019, 9, 69.

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