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Biomolecules 2015, 5(4), 2388-2416;

The Role of the COP9 Signalosome and Neddylation in DNA Damage Signaling and Repair

Department of Pathology, Dalhousie University, Halifax, NS B3H 4R2, Canada
Department of Biochemistry and Molecular Biology, Dalhousie University, Halifax, NS B3H 4R2, Canada
These authors contributed equally to this work.
Author to whom correspondence should be addressed.
Academic Editors: Wolf-Dietrich Heyer, Thomas Helleday and Fumio Hanaoka
Received: 30 June 2015 / Revised: 18 September 2015 / Accepted: 21 September 2015 / Published: 30 September 2015
(This article belongs to the Special Issue DNA Damage Response)
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The maintenance of genomic integrity is an important process in organisms as failure to sense and repair damaged DNA can result in a variety of diseases. Eukaryotic cells have developed complex DNA repair response (DDR) mechanisms to accurately sense and repair damaged DNA. Post-translational modifications by ubiquitin and ubiquitin-like proteins, such as SUMO and NEDD8, have roles in coordinating the progression of DDR. Proteins in the neddylation pathway have also been linked to regulating DDR. Of interest is the COP9 signalosome (CSN), a multi-subunit metalloprotease present in eukaryotes that removes NEDD8 from cullins and regulates the activity of cullin-RING ubiquitin ligases (CRLs). This in turn regulates the stability and turnover of a host of CRL-targeted proteins, some of which have established roles in DDR. This review will summarize the current knowledge on the role of the CSN and neddylation in DNA repair. View Full-Text
Keywords: COP9 Signalosome; DNA repair; NEDD8 COP9 Signalosome; DNA repair; NEDD8

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Chung, D.; Dellaire, G. The Role of the COP9 Signalosome and Neddylation in DNA Damage Signaling and Repair. Biomolecules 2015, 5, 2388-2416.

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