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Macrophage Expression of Inflammatory Genes in Response to EMCV Infection

Department of Biochemistry, Medical College of Wisconsin, 8701 W. Watertown Plank Rd, Milwaukee, WI 53226, USA
Author to whom correspondence should be addressed.
Academic Editor: Ivana Vancurova
Biomolecules 2015, 5(3), 1938-1954;
Received: 16 June 2015 / Revised: 6 August 2015 / Accepted: 8 August 2015 / Published: 18 August 2015
(This article belongs to the Special Issue Transcriptional Regulation of Pro-Inflammatory Genes)
PDF [679 KB, uploaded 18 August 2015]


The expression and production of type 1 interferon is the classic cellular response to virus infection. In addition to this antiviral response, virus infection also stimulates the production of proinflammatory mediators. In this review, the pathways controlling the induction of inflammatory genes and the roles that these inflammatory mediators contribute to host defense against viral pathogens will be discussed. Specific focus will be on the role of the chemokine receptor CCR5, as a signaling receptor controlling the activation of pathways leading to virus-induced inflammatory gene expression. View Full-Text
Keywords: inflammation, cytokine, virus, macrophage, diabetes, Ccr5 inflammation, cytokine, virus, macrophage, diabetes, Ccr5

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Shaheen, Z.R.; Corbett, J.A. Macrophage Expression of Inflammatory Genes in Response to EMCV Infection. Biomolecules 2015, 5, 1938-1954.

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