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Transcriptional Regulation of Chemokine Expression in Ovarian Cancer

Department of Biological Sciences, St. John's University, 8000 Utopia Parkway, New York, NY 11439, USA
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Academic Editor: Jürg Bähler
Biomolecules 2015, 5(1), 223-243; https://doi.org/10.3390/biom5010223
Received: 8 December 2014 / Revised: 4 March 2015 / Accepted: 9 March 2015 / Published: 17 March 2015
(This article belongs to the Special Issue Transcriptional Regulation of Pro-Inflammatory Genes)
The increased expression of pro-inflammatory and pro-angiogenic chemokines contributes to ovarian cancer progression through the induction of tumor cell proliferation, survival, angiogenesis, and metastasis. The substantial potential of these chemokines to facilitate the progression and metastasis of ovarian cancer underscores the need for their stringent transcriptional regulation. In this Review, we highlight the key mechanisms that regulate the transcription of pro-inflammatory chemokines in ovarian cancer cells, and that have important roles in controlling ovarian cancer progression. We further discuss the potential mechanisms underlying the increased chemokine expression in drug resistance, along with our perspective for future studies. View Full-Text
Keywords: chemokines; interleukin-8; NFκB; ovarian cancer; transcriptional regulation chemokines; interleukin-8; NFκB; ovarian cancer; transcriptional regulation
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Singha, B.; Gatla, H.R.; Vancurova, I. Transcriptional Regulation of Chemokine Expression in Ovarian Cancer. Biomolecules 2015, 5, 223-243.

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