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Biomolecules
Volume 15
Issue 12
10.3390/biom15121677
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Review

Modelling Neural Disorders with the D. melanogaster Larval Peripheral and Adult Dopaminergic Systems

by
Daniel Tendero-Lopez
,
Maria Dominguez
* and
Mario Aguilar-Aragon
*
Instituto de Neurociencias, Consejo Superior de Investigaciones Científicas, Universidad Miguel Hernández (CSIC-UMH), 03550 Sant Joan d’Alacant, Spain
*
Authors to whom correspondence should be addressed.
Biomolecules 2025, 15(12), 1677; https://doi.org/10.3390/biom15121677 (registering DOI)
Submission received: 7 October 2025 / Revised: 13 November 2025 / Accepted: 26 November 2025 / Published: 1 December 2025
(This article belongs to the Section Molecular Biology)
Review Reports Versions Notes

Abstract

The increasing prevalence of neurological disorders highlights the need for disease animal models to elucidate the underlying biomolecular and cellular mechanisms of disease and to facilitate studies aimed at developing effective treatments. The fruit fly Drosophila melanogaster, at both larval and adult stages, can serve as an effective model for different human-relevant neurological diseases. Larvae are particularly suited for studying peripheral nervous system disorders, such as Charcot–Marie–Tooth and amyotrophic lateral sclerosis, while adults enable investigations of higher-order cognitive functions and age-related conditions, including Parkinson’s disease and depression-like behaviours. Combining larval and adult models offers a complementary framework to dissect the biomolecular pathways of neurological disorders and accelerate preclinical research.
Keywords: neurological disorders; Drosophila melanogaster; peripheral nervous system; dopamine neurological disorders; Drosophila melanogaster; peripheral nervous system; dopamine

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MDPI and ACS Style

Tendero-Lopez, D.; Dominguez, M.; Aguilar-Aragon, M. Modelling Neural Disorders with the D. melanogaster Larval Peripheral and Adult Dopaminergic Systems. Biomolecules 2025, 15, 1677. https://doi.org/10.3390/biom15121677

AMA Style

Tendero-Lopez D, Dominguez M, Aguilar-Aragon M. Modelling Neural Disorders with the D. melanogaster Larval Peripheral and Adult Dopaminergic Systems. Biomolecules. 2025; 15(12):1677. https://doi.org/10.3390/biom15121677

Chicago/Turabian Style

Tendero-Lopez, Daniel, Maria Dominguez, and Mario Aguilar-Aragon. 2025. "Modelling Neural Disorders with the D. melanogaster Larval Peripheral and Adult Dopaminergic Systems" Biomolecules 15, no. 12: 1677. https://doi.org/10.3390/biom15121677

APA Style

Tendero-Lopez, D., Dominguez, M., & Aguilar-Aragon, M. (2025). Modelling Neural Disorders with the D. melanogaster Larval Peripheral and Adult Dopaminergic Systems. Biomolecules, 15(12), 1677. https://doi.org/10.3390/biom15121677

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