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Article

Postoperative Electroacupuncture Boosts Cognitive Function Recovery after Laparotomy in Mice

by
Yuen-Shan Ho
1,*,
Wai-Yin Cheng
2,3,4,
Michael Siu-Lun Lai
1,
Chi-Fai Lau
1,
Gordon Tin-Chun Wong
5,
Wing-Fai Yeung
1 and
Raymond Chuen-Chung Chang
2,*
1
School of Nursing, Faculty of Health and Social Sciences, The Hong Kong Polytechnic University, Hong Kong SAR, China
2
Laboratory of Neurodegenerative Diseases, School of Biomedical Sciences, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China
3
Research Institute for Future Food, The Hong Kong Polytechnic University, Hong Kong SAR, China
4
Department of Food Science and Nutrition, Faculty of Science, The Hong Kong Polytechnic University, Hong Kong SAR, China
5
Department of Anesthesiology, The University of Hong Kong, Hong Kong SAR, China
*
Authors to whom correspondence should be addressed.
Biomolecules 2024, 14(10), 1274; https://doi.org/10.3390/biom14101274
Submission received: 2 August 2024 / Revised: 4 September 2024 / Accepted: 24 September 2024 / Published: 10 October 2024
(This article belongs to the Special Issue Neurocognitive Disorders: From Molecular Mechanisms to Therapeutic Strategies)
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Abstract

Postoperative cognitive dysfunction (POCD) is a common complication that affects memory, executive function, and processing speed postoperatively. The pathogenesis of POCD is linked to excessive neuroinflammation and pre-existing Alzheimer’s disease (AD) pathology. Previous studies have shown that acupuncture improves cognition in the early phase of POCD. However, POCD can last for longer periods (up to weeks and years). The long-term effects of acupuncture are unknown. In this study, we hypothesized that electroacupuncture (EA) could reduce inflammation and cognitive dysfunction induced by laparotomy over a longer period. We characterized the effects of postoperative EA on cognitive changes and investigated the underlying molecular mechanisms in mice. Laparotomy was performed in 3-month-old mice followed by daily EA treatment for 2 weeks. Our data indicated that laparotomy induced prolonged impairment in memory and executive functions, which were mitigated by postoperative EA. EA also reduced tau phosphorylation and suppressed the activation of tau-related kinases and glia, with effects comparable to ibuprofen. These findings demonstrate the beneficial effects of EA in a mouse model of POCD, suggesting that EA’s ability to suppress neuroinflammation may contribute to its protective effects. In conclusion, EA may be a viable non-pharmacological intervention for managing POCD in different phases of the medical condition.
Keywords: cognition; memory; surgery; acupuncture; Chinese medicine; tau; inflammation cognition; memory; surgery; acupuncture; Chinese medicine; tau; inflammation
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MDPI and ACS Style

Ho, Y.-S.; Cheng, W.-Y.; Lai, M.S.-L.; Lau, C.-F.; Wong, G.T.-C.; Yeung, W.-F.; Chang, R.C.-C. Postoperative Electroacupuncture Boosts Cognitive Function Recovery after Laparotomy in Mice. Biomolecules 2024, 14, 1274. https://doi.org/10.3390/biom14101274

AMA Style

Ho Y-S, Cheng W-Y, Lai MS-L, Lau C-F, Wong GT-C, Yeung W-F, Chang RC-C. Postoperative Electroacupuncture Boosts Cognitive Function Recovery after Laparotomy in Mice. Biomolecules. 2024; 14(10):1274. https://doi.org/10.3390/biom14101274

Chicago/Turabian Style

Ho, Yuen-Shan, Wai-Yin Cheng, Michael Siu-Lun Lai, Chi-Fai Lau, Gordon Tin-Chun Wong, Wing-Fai Yeung, and Raymond Chuen-Chung Chang. 2024. "Postoperative Electroacupuncture Boosts Cognitive Function Recovery after Laparotomy in Mice" Biomolecules 14, no. 10: 1274. https://doi.org/10.3390/biom14101274

APA Style

Ho, Y.-S., Cheng, W.-Y., Lai, M. S.-L., Lau, C.-F., Wong, G. T.-C., Yeung, W.-F., & Chang, R. C.-C. (2024). Postoperative Electroacupuncture Boosts Cognitive Function Recovery after Laparotomy in Mice. Biomolecules, 14(10), 1274. https://doi.org/10.3390/biom14101274

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