Next Article in Journal
Biosensor-Integrated Drug Delivery Systems as New Materials for Biomedical Applications
Previous Article in Journal
Head-to-Head Comparison of Different Blood Collecting Tubes for Quantification of Alzheimer’s Disease Biomarkers in Plasma
Previous Article in Special Issue
Antioxidant and Anti-Inflammatory Properties of Bioavailable Protein Hydrolysates from Lupin-Derived Agri-Waste
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Biomolecules
Volume 12
Issue 9
10.3390/biom12091196
biomolecules-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

Preventive Effect of Epigallocatechin Gallate, the Main Component of Green Tea, on Acute Lung Injury Caused by Air Pollutants

by
Ken-Ichiro Tanaka
1,*,
Shunsuke Nakaguchi
1,
Sachie Shiota
1,
Yuka Nakada
1,
Kaho Oyama
1,
Okina Sakakibara
1,
Mikako Shimoda
1,
Akio Sugimoto
2,
Masaki Ichitani
2,
Takanobu Takihara
2,
Hitoshi Kinugasa
2 and
Masahiro Kawahara
1
1
Laboratory of Bio-Analytical Chemistry, Research Institute of Pharmaceutical Sciences, Musashino University, 1-1-20 Shinmachi, Nishitokyo 202-8585, Japan
2
Central Research Institute, ITO EN, Ltd., 21 Mekami, Makinohara 421-0516, Japan
*
Author to whom correspondence should be addressed.
Biomolecules 2022, 12(9), 1196; https://doi.org/10.3390/biom12091196
Submission received: 4 July 2022 / Revised: 23 August 2022 / Accepted: 26 August 2022 / Published: 29 August 2022
(This article belongs to the Special Issue Antioxidants in Food and Waste from the Agri-Food Industry)
Browse Figures
Versions Notes

Abstract

Reducing the health hazards caused by air pollution is a global challenge and is included in the Sustainable Development Goals. Air pollutants, such as PM2.5, induce respiratory and cardiovascular disorders by causing various inflammatory responses via oxidative stress. Catechins and polyphenols, which are components of green tea, have various protective effects, owing to their antioxidant ability. The main catechin in green tea, epigallocatechin gallate (EGCG), is potentially effective against respiratory diseases, such as idiopathic pulmonary fibrosis and asthma, but its effectiveness against air-pollution-dependent lung injury has not yet been investigated. In this study, we examined the effect of EGCG on urban aerosol-induced acute lung injury in mice. Urban aerosol treatment caused increases in inflammatory cell counts, protein levels, and inflammatory cytokine expression in the lungs of ICR mice, but pretreatment with EGCG markedly suppressed these responses. Analyses of oxidative stress revealed that urban aerosol exposure enhanced reactive oxygen species (ROS) production and the formation of ROS-activated neutrophil extracellular traps (NETs) in the lungs of mice. However, ROS production and NETs formation were markedly suppressed by pretreating the mice with EGCG. Gallocatechin gallate (GCG), a heat-epimerized form of EGCG, also markedly suppressed urban aerosol-dependent inflammatory responses and ROS production in vivo and in vitro. These findings suggest that EGCG and GCG prevent acute lung injury caused by urban aerosols through their inhibitory effects on ROS production. Thus, we believe that foods and medications containing EGCG or GCG may be candidates to prevent the onset and progression of acute lung injury caused by air pollutants.
Keywords: air pollution; oxidative stress; epigallocatechin gallate; reactive oxygen species; neutrophil extracellular traps air pollution; oxidative stress; epigallocatechin gallate; reactive oxygen species; neutrophil extracellular traps

Share and Cite

MDPI and ACS Style

Tanaka, K.-I.; Nakaguchi, S.; Shiota, S.; Nakada, Y.; Oyama, K.; Sakakibara, O.; Shimoda, M.; Sugimoto, A.; Ichitani, M.; Takihara, T.; et al. Preventive Effect of Epigallocatechin Gallate, the Main Component of Green Tea, on Acute Lung Injury Caused by Air Pollutants. Biomolecules 2022, 12, 1196. https://doi.org/10.3390/biom12091196

AMA Style

Tanaka K-I, Nakaguchi S, Shiota S, Nakada Y, Oyama K, Sakakibara O, Shimoda M, Sugimoto A, Ichitani M, Takihara T, et al. Preventive Effect of Epigallocatechin Gallate, the Main Component of Green Tea, on Acute Lung Injury Caused by Air Pollutants. Biomolecules. 2022; 12(9):1196. https://doi.org/10.3390/biom12091196

Chicago/Turabian Style

Tanaka, Ken-Ichiro, Shunsuke Nakaguchi, Sachie Shiota, Yuka Nakada, Kaho Oyama, Okina Sakakibara, Mikako Shimoda, Akio Sugimoto, Masaki Ichitani, Takanobu Takihara, and et al. 2022. "Preventive Effect of Epigallocatechin Gallate, the Main Component of Green Tea, on Acute Lung Injury Caused by Air Pollutants" Biomolecules 12, no. 9: 1196. https://doi.org/10.3390/biom12091196

APA Style

Tanaka, K.-I., Nakaguchi, S., Shiota, S., Nakada, Y., Oyama, K., Sakakibara, O., Shimoda, M., Sugimoto, A., Ichitani, M., Takihara, T., Kinugasa, H., & Kawahara, M. (2022). Preventive Effect of Epigallocatechin Gallate, the Main Component of Green Tea, on Acute Lung Injury Caused by Air Pollutants. Biomolecules, 12(9), 1196. https://doi.org/10.3390/biom12091196

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop